6-(3-benzyloxy-4-methoxy-phenyl)-7-(3,4,5-trimethoxy-phenyl)-2,3,8,8a-tetrahydro-1H-indolizin-5-one

Base Information

• Chemical Name: 6-(3-benzyloxy-4-methoxy-phenyl)-7-(3,4,5-trimethoxy-phenyl)-2,3,8,8a-tetrahydro-1H-indolizin-5-one
• CAS No.: 592528-81-9
• Molecular Formula: C₃₁H₃₃NO₆
• Molecular Weight: 515.606

Synonyms:6-(3-benzyloxy-4-methoxy-phenyl)-7-(3,4,5-trimethoxy-phenyl)-2,3,8,8a-tetrahydro-1H-indolizin-5-one

Chemical Property of 6-(3-benzyloxy-4-methoxy-phenyl)-7-(3,4,5-trimethoxy-phenyl)-2,3,8,8a-tetrahydro-1H-indolizin-5-one

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Technology Process of 6-(3-benzyloxy-4-methoxy-phenyl)-7-(3,4,5-trimethoxy-phenyl)-2,3,8,8a-tetrahydro-1H-indolizin-5-one

There total 4 articles about 6-(3-benzyloxy-4-methoxy-phenyl)-7-(3,4,5-trimethoxy-phenyl)-2,3,8,8a-tetrahydro-1H-indolizin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-{1-[2-(3-Benzyloxy-4-methoxy-phenyl)-acetyl]-pyrrolidin-2-yl}-1-(3,4,5-trimethoxy-phenyl)-ethanone (592529-09-4) → 6-(3-benzyloxy-4-methoxy-phenyl)-7-(3,4,5-trimethoxy-phenyl)-2,3,8,8a-tetrahydro-1H-indolizin-5-one (592528-81-9)

Guidance literature:

With potassium hydroxide; In ethanol; Heating;

DOI:10.1016/S0960-894X(03)00263-4

Reference yield:

methyl 3-oxo-3-(3,4,5-trimethoxyphenyl)propanoate (139148-39-3) → 6-(3-benzyloxy-4-methoxy-phenyl)-7-(3,4,5-trimethoxy-phenyl)-2,3,8,8a-tetrahydro-1H-indolizin-5-one (592528-81-9)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. KOH / 24 h / 20 °C

2: aq. phosphate buffer / 60 h / 20 °C / pH 7.0

3: Et₃N / CH₂Cl₂ / 20 °C

4: KOH / ethanol / Heating

With potassium hydroxide; phosphate buffer; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/S0960-894X(03)00263-4

Reference yield:

3-oxo-3-(3,4,5-trimethoxyphenyl)propionic acid (114195-15-2) → 6-(3-benzyloxy-4-methoxy-phenyl)-7-(3,4,5-trimethoxy-phenyl)-2,3,8,8a-tetrahydro-1H-indolizin-5-one (592528-81-9)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. phosphate buffer / 60 h / 20 °C / pH 7.0

2: Et₃N / CH₂Cl₂ / 20 °C

3: KOH / ethanol / Heating

With potassium hydroxide; phosphate buffer; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/S0960-894X(03)00263-4

upstream raw materials:

2-{1-[2-(3-Benzyloxy-4-methoxy-phenyl)-acetyl]-pyrrolidin-2-yl}-1-(3,4,5-trimethoxy-phenyl)-ethanone

methyl 3-oxo-3-(3,4,5-trimethoxyphenyl)propanoate

3-oxo-3-(3,4,5-trimethoxyphenyl)propionic acid

2-pyrrolidin-2-yl-1-(3,4,5-trimethoxy-phenyl)-ethanone

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