Cinnamylamine hydrochloride

Base Information

• Chemical Name: Cinnamylamine hydrochloride
• CAS No.: 5586-89-0
• Molecular Formula: C9H11 N . Cl H
• Molecular Weight: 169.654
• European Community (EC) Number: 695-318-5,837-674-8
• UNII: 18K2HTU6KP
• Mol file: 5586-89-0.mol

Synonyms:5586-89-0;CINNAMYLAMINE HYDROCHLORIDE;17480-08-9;CINNAMYLAMINE, HYDROCHLORIDE;3-phenylprop-2-en-1-amine hydrochloride;Cinnamylamine hydrochloride, (E)-;(E)-3-phenylprop-2-en-1-amine hydrochloride;Phenylallylamine hydrochloride;Cinnamylamine, hydrochloride, (E)-;UNII-18K2HTU6KP;18K2HTU6KP;UNII-804RO62BS2;2-Propen-1-amine, 3-phenyl-, hydrochloride;(E)-3-phenylprop-2-en-1-amine;hydrochloride;(2E)-3-phenylprop-2-en-1-amine hydrochloride;[(2E)-3-phenylprop-2-en-1-yl]amine hydrochloride;2-Propen-1-amine, 3-phenyl-, hydrochloride (1:1), (2E)-;(2Z)-3-phenylprop-2-en-1-amine hydrochloride, Z;trans-3-Phenylallylamine Hydrochloride (Cinnamylamine Hydrochloride);(E)-3-PHENYLPROP-2-EN-1-AMINE HCL;(E)-cinnamylamine hydrochloride;SCHEMBL6314436;trans-cinnamylamine hydrochloride;trans-cinnamylamine-hydrochloride;RHJVYCBQGSIGEG-KQGICBIGSA-N;804RO62BS2;AKOS025213517;LS-54247;MS-20634;(E)-3-phenylprop-2-en-1-aminehydrochloride;[(2E)-3-Phenylprop-2-en-1-yl]amine HCl;(2E)-3-Phenyl-2-propen-1-amine hydrochloride;EN300-127415;EN300-717556;W12746;[(2E)-3-phenyl-2-propen-1-yl]amine hydrochloride;Q27252015

Chemical Property of Cinnamylamine hydrochloride

Chemical Property:

• Vapor Pressure: 0.0181mmHg at 25°C
• Melting Point: 235 °C
• Boiling Point: 253.6°Cat760mmHg
• Flash Point: 105.4°C
• PSA: 26.02000
• Density: g/cm³
• LogP: 3.16080
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Sparingly, Sonicated), Methanol (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 169.0658271
• Heavy Atom Count: 11
• Complexity: 101

Purity/Quality:

98%min ^*data from raw suppliers

Tranylcypromine Related Compound B United States Pharmacopeia (USP) Reference Standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C=CCN.Cl
• Isomeric SMILES: C1=CC=C(C=C1)/C=C/CN.Cl
• Uses: Cinnamylamine Hydrochloride, can be used for the preparation of Tranylcypromine, a drug that acts as a nonselective and irreversible inhibitor of the enzyme monoamine oxidase (MAO), and is used as an antidepressant and anxiolytic agent.

Technology Process of Cinnamylamine hydrochloride

There total 9 articles about Cinnamylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(3-azidoprop-1-en-1-yl)benzene (57294-86-7) → 3-phenylprop-2-en-1-amine hydrochloride (5586-89-0)

Guidance literature:

(3-azidoprop-1-en-1-yl)benzene; With 1,3-diphenyl-disiloxane; triphenylphosphine; at 20 ℃; for 24h;

With water;

With hydrogenchloride; In 1,4-dioxane; chemoselective reaction;

DOI:10.1021/acs.joc.9b00831

Reference yield: 88.0%

1-(cinnamyl)-3,4-diphenyl-1H-pyrrole-2,5-dione → 2,3-diphenylmaleic anhydride (4808-48-4) + 3-phenylprop-2-en-1-amine hydrochloride (5586-89-0)

Guidance literature:

1-(cinnamyl)-3,4-diphenyl-1H-pyrrole-2,5-dione; With potassium hydroxide; In ethanol; water; at 102 ℃; for 0.133333h; Microwave irradiation; Green chemistry;

With hydrogenchloride; In ethanol; water; pH=4; Temperature; Green chemistry;

DOI:10.1039/c6gc01318j

Reference yield: 71.0%

C18H28NO5P (85231-94-3) → 3-phenylprop-2-en-1-amine hydrochloride (5586-89-0)

Guidance literature:

With hydrogenchloride; In benzene; Ambient temperature;

DOI:10.1055/s-1982-29997

upstream raw materials:

(E)-3-Phenyl-allyl-phosphorimidic acid triethyl ester

C₁₈H₂₈NO₅P

(3-azidoprop-1-en-1-yl)benzene

Cinnamyl bromide

Downstream raw materials:

cinnamyl chloride

C₂₃H₂₉NO₉