3-{2-fluoro-3-(methylaminosulfonyl)aminobenzyl}-4-methyl-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

Base Information

Chemical Name:3-{2-fluoro-3-(methylaminosulfonyl)aminobenzyl}-4-methyl-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran
CAS No.:946128-76-3
Molecular Formula:C₂₂H₁₉FN₄O₅S
Molecular Weight:470.481
Hs Code.:

Synonyms:3-{2-fluoro-3-(methylaminosulfonyl)aminobenzyl}-4-methyl-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

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Chemical Property of 3-{2-fluoro-3-(methylaminosulfonyl)aminobenzyl}-4-methyl-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

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Technology Process of 3-{2-fluoro-3-(methylaminosulfonyl)aminobenzyl}-4-methyl-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

There total 9 articles about 3-{2-fluoro-3-(methylaminosulfonyl)aminobenzyl}-4-methyl-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 946126-42-7
4-methyl-3-(2-fluoro-3-aminobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

: 10438-96-7
N-methylsulfamoyl chloride

: 946128-76-3
3-{2-fluoro-3-(methylaminosulfonyl)aminobenzyl}-4-methyl-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

Guidance literature:: With pyridine; In N,N-dimethyl-formamide; acetonitrile; at 0 - 20 ℃; for 2h;

Reference yield: 63.0%

: 898798-37-3
N-methyl-2-oxo-1,3-oxazolidine-3-sulfonamide

: 946126-42-7
4-methyl-3-(2-fluoro-3-aminobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

: 946128-76-3
3-{2-fluoro-3-(methylaminosulfonyl)aminobenzyl}-4-methyl-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

Guidance literature:: With triethylamine; In acetonitrile; at 20 - 75 ℃; for 3.5h;
DOI:10.1021/ml4002419 DOI:10.1021/ml400379x

Reference yield:

: 946125-65-1
1-(bromomethyl)-2-fluoro-3- nitrobenzene

: 946128-76-3
3-{2-fluoro-3-(methylaminosulfonyl)aminobenzyl}-4-methyl-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 12 h / 0 - 20 °C / Inert atmosphere

2.1: sulfuric acid / 12 h / 0 - 20 °C

3.1: tin(II) chloride dihdyrate / ethyl acetate / 15 h / 20 °C / Reflux

4.1: caesium carbonate / N,N-dimethyl-formamide / 0.67 h / 100 °C

5.1: triethylamine / acetonitrile / 3.5 h / 20 - 75 °C

With tin(II) chloride dihdyrate; sulfuric acid; sodium hydride; caesium carbonate; triethylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil; 2.1: |Pechmann Condensation;
DOI:10.1021/ml4002419