946126-42-7

Basic information

• Product Name: 4-methyl-3-(2-fluoro-3-aminobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran
• Synonyms: 4-methyl-3-(2-fluoro-3-aminobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran
• CAS NO: 946126-42-7
• Molecular Weight: 377.375
• Mol File: 946126-42-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-methyl-3-(2-fluoro-3-aminobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-3-(2-fluoro-3-aminobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran(946126-42-7)
• EPA Substance Registry System: 4-methyl-3-(2-fluoro-3-aminobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran(946126-42-7)

Safety Data

• Hazardous Substances Data: 946126-42-7(Hazardous Substances Data)

Upstream product

• 3970-35-2 2-chloro-3-nitrobezoic acid 
• 946126-95-0 (2-fluoro-3-nitrophenyl)methanol 
• 946126-94-9 2-fluoro-3-nitrobenzoic acid methyl ester 
• 53553-14-3 2-chloro-3-nitrobenzoic acid methyl ester 
• 946130-13-8 3-(2-fluoro-3-nitrobenzyl)-7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran 
• 946130-07-0 2-(2-fluoro-3-nitrobenzyl)-3-oxo-butyric acid ethyl ester 
• 946125-65-1 1-(bromomethyl)-2-fluoro-3- nitrobenzene 
• 437-86-5 2-fluoro-3-nitrotoluene 
• 3970-40-9 2-chloro-3-nitrotoluene 
• 946126-04-1 4-methyl-3-(2-fluoro-3-nitrobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran 
• 946126-97-2 2-oxo-2H-3-(2-fluoro-3-aminobenzyl)-4-methyl-7-hydroxy-1-benzopyran 
• 4595-60-2 2-bromopyrimidine 

Downstream Products

• 946126-93-8 C₂₃H₁₈FN₃O₇S 
• 946128-76-3 3-{2-fluoro-3-(methylaminosulfonyl)aminobenzyl}-4-methyl-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran 
• 946129-85-7 2-{2-fluoro-3-[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-1-benzopyran-3-ylmethyl]phenylsulfamoyl}-N-methylacetamide 

Relevant articles and documents

MEK INHIBITORS AND THERAPEUTIC USES THEREOF

The present disclosure provides compounds, compositions containing such compounds, and methods of designing, developing, producing and preparing compounds represented by general Formula (I), including pharmaceutically acceptable salts thereof or a synthetic intermediate thereof. The compounds act as MEK inhibitors and are capable of displaying one or more beneficial therapeutic effects, including treating cancer.

Optimizing the physicochemical properties of Raf/MEK inhibitors by nitrogen scanning

Substituting a carbon atom with a nitrogen atom (nitrogen substitution) on an aromatic ring in our leads 11a and 13g by applying nitrogen scanning afforded a set of compounds that improved not only the solubility but also the metabolic stability. The impa

p27 PROTEIN INDUCER

The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G1, G2, G3 and G8 are each independently selected from -N= etc., Ring G6 is selected from divalent aryl etc., A is selected from amino etc., G4 is selected from oxygen etc., G5 is selected from oxygen etc., G7 is selected from -CH2- etc., and R2 is selected from C1-6 alkyl etc.