(E)-4-(4-fluorophenyl)-6-(4-methoxystyryl)-2-oxo-N-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide

Base Information

• Chemical Name: (E)-4-(4-fluorophenyl)-6-(4-methoxystyryl)-2-oxo-N-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide
• CAS No.: 1565871-20-6
• Molecular Formula: C₂₆H₂₂FN₃O₃
• Molecular Weight: 443.477

Synonyms:(E)-4-(4-fluorophenyl)-6-(4-methoxystyryl)-2-oxo-N-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide

Chemical Property of (E)-4-(4-fluorophenyl)-6-(4-methoxystyryl)-2-oxo-N-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide

Chemical Property:

Purity/Quality:

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Technology Process of (E)-4-(4-fluorophenyl)-6-(4-methoxystyryl)-2-oxo-N-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide

There total 3 articles about (E)-4-(4-fluorophenyl)-6-(4-methoxystyryl)-2-oxo-N-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-(4-fluorophenyl)-6-methyl-2-oxo-N-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide (333768-16-4) + 4-methoxy-benzaldehyde (123-11-5) → (E)-4-(4-fluorophenyl)-6-(4-methoxystyryl)-2-oxo-N-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide (1565871-20-6)

Guidance literature:

4-(4-fluorophenyl)-6-methyl-2-oxo-N-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide; 4-methoxy-benzaldehyde; With iron(III) chloride hexahydrate; In acetonitrile; for 12h; Reflux;

DOI:10.1021/jo402773r

Reference yield:

N-phenylacetoacetamide (102-01-2,98624-45-4) → (E)-4-(4-fluorophenyl)-6-(4-methoxystyryl)-2-oxo-N-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide (1565871-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: iron(III) chloride hexahydrate / acetonitrile / 5 h / Reflux

2: iron(III) chloride hexahydrate / acetonitrile / 27 h / Reflux

With iron(III) chloride hexahydrate; In acetonitrile;

DOI:10.1016/j.tet.2015.07.039

Reference yield:

4-fluorobenzaldehyde (459-57-4) → (E)-4-(4-fluorophenyl)-6-(4-methoxystyryl)-2-oxo-N-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide (1565871-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: iron(III) chloride hexahydrate / acetonitrile / 5 h / Reflux

2: iron(III) chloride hexahydrate / acetonitrile / 27 h / Reflux

With iron(III) chloride hexahydrate; In acetonitrile;

DOI:10.1016/j.tet.2015.07.039

upstream raw materials:

4-(4-fluorophenyl)-6-methyl-2-oxo-N-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide

4-methoxy-benzaldehyde

N-phenylacetoacetamide

4-fluorobenzaldehyde

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