8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline

Base Information

• Chemical Name: 8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline
• CAS No.: 1431697-05-0
• Molecular Formula: C₁₈H₁₉NO₃
• Molecular Weight: 297.354

Synonyms:8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline

Chemical Property of 8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline

Chemical Property:

Purity/Quality:

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• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline

There total 2 articles about 8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H21NO4 (1431664-70-8) → 8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline (1431697-05-0)

Guidance literature:

With sulfuric acid; In dichloromethane; for 2h;

DOI:10.1016/j.tetlet.2013.03.076

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline (1431697-05-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: benzene / Reflux; Dean-Stark

2.1: magnesium / tetrahydrofuran / 0 °C

2.2: 20 °C

3.1: sulfuric acid / dichloromethane / 2 h

With sulfuric acid; magnesium; In tetrahydrofuran; dichloromethane; benzene;

DOI:10.1016/j.tetlet.2013.03.076

Reference yield:

8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline (1431697-05-0) → 8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline hydrochloride (1431664-72-0)

Guidance literature:

With acetyl chloride; isopropyl alcohol; In water;

DOI:10.1016/j.tetlet.2013.03.076

upstream raw materials:

4-methoxy-benzaldehyde

C₁₈H₂₁NO₄

Downstream raw materials:

8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline hydrochloride

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