8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline hydrochloride

Base Information

• Chemical Name: 8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline hydrochloride
• CAS No.: 1431664-72-0
• Molecular Formula: C₁₈H₁₉NO₃*ClH
• Molecular Weight: 333.815

Synonyms:8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline hydrochloride

Chemical Property of 8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline hydrochloride

There total 4 articles about 8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline (1431697-05-0) → 8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline hydrochloride (1431664-72-0)

Guidance literature:

With acetyl chloride; isopropyl alcohol; In water;

DOI:10.1016/j.tetlet.2013.03.076

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline hydrochloride (1431664-72-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: benzene / Reflux; Dean-Stark

2.1: magnesium / tetrahydrofuran / 0 °C

2.2: 20 °C

3.1: sulfuric acid / dichloromethane / 2 h

4.1: isopropyl alcohol; acetyl chloride / water

With sulfuric acid; magnesium; acetyl chloride; isopropyl alcohol; In tetrahydrofuran; dichloromethane; water; benzene;

DOI:10.1016/j.tetlet.2013.03.076

Reference yield:

C11H15NO2 (1431664-68-4) → 8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline hydrochloride (1431664-72-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: magnesium / tetrahydrofuran / 0 °C

1.2: 20 °C

2.1: sulfuric acid / dichloromethane / 2 h

3.1: isopropyl alcohol; acetyl chloride / water

With sulfuric acid; magnesium; acetyl chloride; isopropyl alcohol; In tetrahydrofuran; dichloromethane; water;

DOI:10.1016/j.tetlet.2013.03.076

upstream raw materials:

8-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline

4-methoxy-benzaldehyde

C₁₁H₁₅NO₂

C₁₈H₂₁NO₄

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