(2R,3R)-carbonic acid benzyl ester 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxytridecyl ester

Base Information

Chemical Name:(2R,3R)-carbonic acid benzyl ester 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxytridecyl ester
CAS No.:377082-62-7
Molecular Formula:C₃₆H₄₅NO₆
Molecular Weight:587.756
Hs Code.:

Synonyms:(2R,3R)-carbonic acid benzyl ester 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxytridecyl ester

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Chemical Property of (2R,3R)-carbonic acid benzyl ester 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxytridecyl ester

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Technology Process of (2R,3R)-carbonic acid benzyl ester 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxytridecyl ester

There total 6 articles about (2R,3R)-carbonic acid benzyl ester 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxytridecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 377082-56-9
(2R,3R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)tridecane-1,3-diol

: 377082-62-7
(2R,3R)-carbonic acid benzyl ester 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxytridecyl ester

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 - 20 ℃; for 48h;
DOI:10.1021/jo015844v

Reference yield:

: 17049-50-2
n-decyl magnesium bromide

: 377082-62-7
(2R,3R)-carbonic acid benzyl ester 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxytridecyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: iBu₅Al₂H / CH₂Cl₂; hexane / 0.75 h / -78 °C

1.2: 72 percent / CH₂Cl₂; hexane; diethyl ether / -78 - 20 °C

2.1: aq. HCl / tetrahydrofuran / 2 h / 20 °C

3.1: 110.1 mg / dioxane / 20 °C

4.1: 96 percent / DMAP; iPr₂NEt / CH₂Cl₂ / 48 h / -78 - 20 °C

With hydrogenchloride; dmap; i-Bu₂AlH*i-Bu₃Al; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;
DOI:10.1021/jo015844v

Reference yield:

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 377082-62-7
(2R,3R)-carbonic acid benzyl ester 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxytridecyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 110.1 mg / dioxane / 20 °C

2: 96 percent / DMAP; iPr₂NEt / CH₂Cl₂ / 48 h / -78 - 20 °C

With dmap; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jo015844v