8-(3-amino-4-hydroxyphenyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene

Base Information

Chemical Name:8-(3-amino-4-hydroxyphenyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene
CAS No.:1181844-41-6
Molecular Formula:C₁₉H₂₀BF₂N₃O
Molecular Weight:355.195
Hs Code.:

Synonyms:8-(3-amino-4-hydroxyphenyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene

Suppliers and Price of 8-(3-amino-4-hydroxyphenyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-(3-amino-4-hydroxyphenyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene

Chemical Property:

Melting Point:>200 °C(Solv: chloroform (67-66-3); hexane (110-54-3))

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 8-(3-amino-4-hydroxyphenyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene

There total 3 articles about 8-(3-amino-4-hydroxyphenyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.8%

: 1181844-40-5
8-(3-nitro-4-hydroxyphenyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene

: 1181844-41-6
8-(3-amino-4-hydroxyphenyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene

Guidance literature:: With hydrogenchloride; methanol; iron; In water; for 2h; Reflux;
DOI:10.1007/s10895-020-02544-9

Reference yield: 75.0%

: 1181844-40-5
8-(3-nitro-4-hydroxyphenyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene

: 7732-18-5
water

: 1181844-41-6
8-(3-amino-4-hydroxyphenyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene

Guidance literature:: With Fe; HCl; In methanol; water; H2O and Fe were added to the soln. of borate-compound in methanol, the mixt. was heated to reflux, a soln. of HCl in methanol was added dropwise, the soln. was refluxed for 2 h, cooled to room temp.; filtered, concd. at reduced pressure, flash column chromy. on silica gel(20% ethyl acetate-petroleum ether), recrystd. from CHCl3-hexane; elem. anal.;
DOI:10.1039/b902912e

Reference yield:

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 3011-34-5
4-hydroxy-3-nitrobenzaldehyde

: 1181844-41-6
8-(3-amino-4-hydroxyphenyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

1.2: 2 h / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / dichloromethane / 5 h / 20 °C

With palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; In dichloromethane;
DOI:10.1039/c6tb03382b