N,N-diethyl-2-(4-fluorophenyl)-2-oxo-acetamide

Base Information

• Chemical Name: N,N-diethyl-2-(4-fluorophenyl)-2-oxo-acetamide
• CAS No.: 166312-56-7
• Molecular Formula: C₁₂H₁₄FNO₂
• Molecular Weight: 223.247
• Mol file: 166312-56-7.mol

Synonyms:N,N-diethyl-2-(4-fluorophenyl)-2-oxo-acetamide

Chemical Property of N,N-diethyl-2-(4-fluorophenyl)-2-oxo-acetamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N,N-diethyl-2-(4-fluorophenyl)-2-oxo-acetamide

There total 6 articles about N,N-diethyl-2-(4-fluorophenyl)-2-oxo-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-fluoro-1-iodobenzene (352-34-1) + carbon monoxide (201230-82-2) + diethylamine (109-89-7) → N,N-diethyl-2-(4-fluorophenyl)-2-oxo-acetamide (166312-56-7)

Guidance literature:

With SingaCycle-A₁; potassium carbonate; In 1,4-dioxane; at 80 ℃; for 12h; under 30003 Torr; Autoclave;

DOI:10.1039/c4ob01878h

Reference yield: 82.0%

N-formyldiethylamine (617-84-5) + 1-(4-fluorophenyl)ethanone (403-42-9) → N,N-diethyl-2-(4-fluorophenyl)-2-oxo-acetamide (166312-56-7)

Guidance literature:

With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; In water; at 100 ℃; for 16h;

DOI:10.1039/c2cc35279f

Reference yield: 67.0%

2-(4-fluorophenyl)-2-oxoacetic acid (2251-76-5) + triethylamine (121-44-8) → N,N-diethyl-2-(4-fluorophenyl)-2-oxo-acetamide (166312-56-7)

Guidance literature:

With silver (II) carbonate; dipotassium peroxodisulfate; In tetrachloromethane; N,N-dimethyl-formamide; at 120 ℃; for 12h;

DOI:10.1039/c3ob40619a

upstream raw materials:

N-formyldiethylamine

1-(4-fluorophenyl)ethanone

2-(4-fluorophenyl)-2-oxoacetic acid

triethylamine