6-(benzyloxy)-1-[4-(benzyloxy)-3-methoxybenzyl]-7-methoxy-3,4-dihydroisoquinoline

Base Information

Chemical Name:6-(benzyloxy)-1-[4-(benzyloxy)-3-methoxybenzyl]-7-methoxy-3,4-dihydroisoquinoline
CAS No.:806600-50-0
Molecular Formula:C₃₂H₃₁NO₄
Molecular Weight:493.602
Hs Code.:

Synonyms:6-(benzyloxy)-1-[4-(benzyloxy)-3-methoxybenzyl]-7-methoxy-3,4-dihydroisoquinoline

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Chemical Property of 6-(benzyloxy)-1-[4-(benzyloxy)-3-methoxybenzyl]-7-methoxy-3,4-dihydroisoquinoline

Chemical Property:

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Technology Process of 6-(benzyloxy)-1-[4-(benzyloxy)-3-methoxybenzyl]-7-methoxy-3,4-dihydroisoquinoline

There total 14 articles about 6-(benzyloxy)-1-[4-(benzyloxy)-3-methoxybenzyl]-7-methoxy-3,4-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 4672-96-2
2-[4-(benzyloxy)-3-methoxyphenyl]-N-[3-(benzyloxy)-4-methoxyphenethyl]acetamide

: 806600-50-0
6-(benzyloxy)-1-[4-(benzyloxy)-3-methoxybenzyl]-7-methoxy-3,4-dihydroisoquinoline

Guidance literature:: With trichlorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/jo061810h

Reference yield:

: 100-39-0
benzyl bromide

: 806600-50-0
6-(benzyloxy)-1-[4-(benzyloxy)-3-methoxybenzyl]-7-methoxy-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / ethanol / 3 h / Reflux

2: ammonium acetate; acetic acid / 0.5 h / Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: sodium carbonate / dichloromethane; water / 3 h / 20 °C

5: trichlorophosphate / acetonitrile / 2 h / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; ammonium acetate; sodium carbonate; potassium carbonate; acetic acid; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1002/asia.201500611

Reference yield:

: 621-59-0
isovanillin

: 806600-50-0
6-(benzyloxy)-1-[4-(benzyloxy)-3-methoxybenzyl]-7-methoxy-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / ethanol / 3 h / Reflux

2: ammonium acetate; acetic acid / 0.5 h / Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: sodium carbonate / dichloromethane; water / 3 h / 20 °C

5: trichlorophosphate / acetonitrile / 2 h / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; ammonium acetate; sodium carbonate; potassium carbonate; acetic acid; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1002/asia.201500611