ethyl 1-(4-benzyloxy-3-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-8-benzyloxy-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Base Information

Chemical Name:ethyl 1-(4-benzyloxy-3-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-8-benzyloxy-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate
CAS No.:919082-39-6
Molecular Formula:C₅₈H₅₃NO₉
Molecular Weight:908.06
Hs Code.:

ethyl 1-(4-benzyloxy-3-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-8-benzyloxy-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Synonyms:ethyl 1-(4-benzyloxy-3-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-8-benzyloxy-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

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Chemical Property of ethyl 1-(4-benzyloxy-3-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-8-benzyloxy-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

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Technology Process of ethyl 1-(4-benzyloxy-3-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-8-benzyloxy-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

There total 8 articles about ethyl 1-(4-benzyloxy-3-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-8-benzyloxy-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 806600-50-0
6-(benzyloxy)-1-[4-(benzyloxy)-3-methoxybenzyl]-7-methoxy-3,4-dihydroisoquinoline

: 1034028-91-5
(Z)-ethyl 2,4-bis(benzyloxy)-5-methoxy-α-nitrocinnamate

: 919082-39-6
ethyl 1-(4-benzyloxy-3-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-8-benzyloxy-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In acetonitrile; for 18h; Heating;
DOI:10.1021/jo061810h

Reference yield:

: 100-39-0
benzyl bromide

: 919082-39-6
ethyl 1-(4-benzyloxy-3-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-8-benzyloxy-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

2: sodium hydrogencarbonate / acetonitrile / 18 h / Heating

With sodium hydrogencarbonate; In acetonitrile;
DOI:10.1021/jo061810h

Reference yield:

: 621-59-0
isovanillin

: 919082-39-6
ethyl 1-(4-benzyloxy-3-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-8-benzyloxy-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / acetone / 6 h / Heating

2: acetic acid; ethylenediamine / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 20 °C

4: sodium carbonate / dichloromethane; water / 2 h / 20 °C

5: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

6: sodium hydrogencarbonate / acetonitrile / 18 h / Heating

With lithium aluminium tetrahydride; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; acetic acid; ethylenediamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile; 2: Knoevenagel reaction / 5: Bischler-Napieralski reaction;
DOI:10.1021/jo061810h