5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate

Base Information

Chemical Name:5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate
CAS No.:1337541-44-2
Molecular Formula:C₁₈H₁₈N₂O₂S
Molecular Weight:326.419
Hs Code.:

Synonyms:5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate

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Chemical Property of 5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate

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Technology Process of 5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate

There total 7 articles about 5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1337541-37-3
1-tert-butyl 5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate

: 1337541-44-2
5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.3987/COM-11-12244

Reference yield:

: 1337541-30-6
1-tert-butyl 5-ethyl 4-chloro-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate

: 1337541-44-2
5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / N,N-dimethyl acetamide / 4 h / 60 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl acetamide; 1: Suzuki-Miyaura cross-coupling;
DOI:10.3987/COM-11-12244

Reference yield:

: 96962-33-3
ethyl 2-methyl-4-phenyl-1,4,5,6-tetrahydropyrimidin-6-one-5-carboxylate

: 1337541-44-2
5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: P,P-dichlorophenylphosphine oxide / 5 h / 110 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

3: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / N,N-dimethyl acetamide / 4 h / 60 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

With P,P-dichlorophenylphosphine oxide; bis-triphenylphosphine-palladium(II) chloride; sodium hydride; caesium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil; 3: Suzuki-Miyaura cross-coupling;
DOI:10.3987/COM-11-12244