1-tert-butyl 5-ethyl 4-chloro-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 5-ethyl 4-chloro-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate
CAS No.:1337541-30-6
Molecular Formula:C₁₉H₂₃ClN₂O₄
Molecular Weight:378.856
Hs Code.:

Synonyms:1-tert-butyl 5-ethyl 4-chloro-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate

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Chemical Property of 1-tert-butyl 5-ethyl 4-chloro-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate

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Technology Process of 1-tert-butyl 5-ethyl 4-chloro-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate

There total 5 articles about 1-tert-butyl 5-ethyl 4-chloro-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 100416-57-7
ethyl 6-chloro-2-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylate

: 1337541-30-6
1-tert-butyl 5-ethyl 4-chloro-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; regiospecific reaction; Inert atmosphere;
DOI:10.3987/COM-11-12244

Reference yield:

: 96962-33-3
ethyl 2-methyl-4-phenyl-1,4,5,6-tetrahydropyrimidin-6-one-5-carboxylate

: 1337541-30-6
1-tert-butyl 5-ethyl 4-chloro-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: P,P-dichlorophenylphosphine oxide / 5 h / 110 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

With P,P-dichlorophenylphosphine oxide; sodium hydride; In N,N-dimethyl-formamide; mineral oil;
DOI:10.3987/COM-11-12244

Reference yield:

: 100-52-7
benzaldehyde

: 1337541-30-6
1-tert-butyl 5-ethyl 4-chloro-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine; benzoic acid / Inert atmosphere

2: sodium ethanolate / ethanol / 2 h / Reflux; Inert atmosphere

3: P,P-dichlorophenylphosphine oxide / 5 h / 110 °C / Inert atmosphere

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

With piperidine; P,P-dichlorophenylphosphine oxide; sodium ethanolate; sodium hydride; benzoic acid; In ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.3987/COM-11-12244