1-tert-butyl 5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate
CAS No.:1337541-37-3
Molecular Formula:C₂₃H₂₆N₂O₄S
Molecular Weight:426.536
Hs Code.:

Synonyms:1-tert-butyl 5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate

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Chemical Property of 1-tert-butyl 5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate

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Technology Process of 1-tert-butyl 5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate

There total 6 articles about 1-tert-butyl 5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 6165-69-1
Thien-3-ylboronic acid

: 1337541-30-6
1-tert-butyl 5-ethyl 4-chloro-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate

: 1337541-37-3
1-tert-butyl 5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; In N,N-dimethyl acetamide; at 60 ℃; for 4h; Inert atmosphere;
DOI:10.3987/COM-11-12244

Reference yield:

: 100416-57-7
ethyl 6-chloro-2-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylate

: 1337541-37-3
1-tert-butyl 5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / N,N-dimethyl acetamide / 4 h / 60 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium hydride; caesium carbonate; In N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil; 2: Suzuki-Miyaura cross-coupling;
DOI:10.3987/COM-11-12244

Reference yield:

: 100-52-7
benzaldehyde

: 1337541-37-3
1-tert-butyl 5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: piperidine; benzoic acid / Inert atmosphere

2: sodium ethanolate / ethanol / 2 h / Reflux; Inert atmosphere

3: P,P-dichlorophenylphosphine oxide / 5 h / 110 °C / Inert atmosphere

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

5: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / N,N-dimethyl acetamide / 4 h / 60 °C / Inert atmosphere

With piperidine; P,P-dichlorophenylphosphine oxide; bis-triphenylphosphine-palladium(II) chloride; sodium ethanolate; sodium hydride; caesium carbonate; benzoic acid; In ethanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil; 5: Suzuki-Miyaura cross-coupling;
DOI:10.3987/COM-11-12244