N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-2-(4-methylphenylsulfonamido)-4-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-2-(4-methylphenylsulfonamido)-4-(trifluoromethyl)benzamide
CAS No.:1570135-17-9
Molecular Formula:C₂₄H₂₀F₃N₃O₄S
Molecular Weight:503.502
Hs Code.:

Synonyms:N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-2-(4-methylphenylsulfonamido)-4-(trifluoromethyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-2-(4-methylphenylsulfonamido)-4-(trifluoromethyl)benzamide

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Technology Process of N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-2-(4-methylphenylsulfonamido)-4-(trifluoromethyl)benzamide

There total 3 articles about N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-2-(4-methylphenylsulfonamido)-4-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1570134-86-9
N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-4-(trifluoromethyl)benzamide

: 70-55-3
toluene-4-sulfonamide

: 1570135-17-9
N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-2-(4-methylphenylsulfonamido)-4-(trifluoromethyl)benzamide

Guidance literature:: With copper diacetate; sodium carbonate; In dimethyl sulfoxide; at 80 ℃; for 6h;
DOI:10.1021/ja412880r

Reference yield:

: 455-24-3
4-trifluoromethylbenzoic acid

: 1570135-17-9
N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-2-(4-methylphenylsulfonamido)-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide

2: triethylamine / tetrahydrofuran / 6 h / 20 °C

3: copper diacetate; sodium carbonate / dimethyl sulfoxide / 6 h / 80 °C

With oxalyl dichloride; copper diacetate; sodium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja412880r

Reference yield:

: 3416-93-1
2-(4,5-Dihydro-1,3-oxazol-2-yl)aniline

: 329-15-7
4-trifluoromethyl-phenyl acetyl chloride

: 1570135-17-9
N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-2-(4-methylphenylsulfonamido)-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 6 h / 20 °C

2: copper diacetate; sodium carbonate / dimethyl sulfoxide / 6 h / 80 °C

With copper diacetate; sodium carbonate; triethylamine; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/ja412880r