1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-cis-1,4-diol

Base Information

Chemical Name:1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-cis-1,4-diol
CAS No.:1224948-81-5
Molecular Formula:C₂₄H₂₄F₃NO₃S
Molecular Weight:463.521
Hs Code.:

Synonyms:1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-cis-1,4-diol

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Chemical Property of 1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-cis-1,4-diol

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Technology Process of 1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-cis-1,4-diol

There total 6 articles about 1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-cis-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1224948-77-9
4-hydroxy-4-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)cyclohexan-1-one

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 1224948-80-4
1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-trans-1,4-diol

: 1224948-81-5
1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-cis-1,4-diol

Guidance literature:: 4-hydroxy-4-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)cyclohexan-1-one; (trifluoromethyl)trimethylsilane; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.166667h;

With tetrabutyl ammonium fluoride; water; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

: 30482-24-7
1,4-dioxaspiro<4,5>decane-8-carboxamide

: 1224948-80-4
1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-trans-1,4-diol

: 1224948-81-5
1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-cis-1,4-diol

Guidance literature:: Multi-step reaction with 5 steps

1.1: Lawessons reagent / toluene / 1 h / 100 °C

2.1: acetonitrile / 4 h / 20 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

3.2: -78 - 20 °C

4.1: hydrogenchloride; water / tetrahydrofuran / 14 h / 0 - 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

5.2: 0.5 h / 20 °C

With Lawessons reagent; hydrogenchloride; n-butyllithium; tetrabutyl ammonium fluoride; water; In tetrahydrofuran; hexane; toluene; acetonitrile;

Reference yield:

: 66500-55-8
cyclohexanone-4-carboxylic acid ethyleneacetal

: 1224948-80-4
1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-trans-1,4-diol

: 1224948-81-5
1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-cis-1,4-diol

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; propoxycarbonyl chloride / tetrahydrofuran / 1.5 h / 0 - 20 °C

1.2: 1 h / 20 °C

2.1: Lawessons reagent / toluene / 1 h / 100 °C

3.1: acetonitrile / 4 h / 20 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

4.2: -78 - 20 °C

5.1: hydrogenchloride; water / tetrahydrofuran / 14 h / 0 - 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

6.2: 0.5 h / 20 °C

With Lawessons reagent; hydrogenchloride; n-butyllithium; tetrabutyl ammonium fluoride; water; triethylamine; propoxycarbonyl chloride; In tetrahydrofuran; hexane; toluene; acetonitrile;