1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-trans-1,4-diol

Base Information

• Chemical Name: 1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-trans-1,4-diol
• CAS No.: 1224948-80-4
• Molecular Formula: C₂₄H₂₄F₃NO₃S
• Molecular Weight: 463.521
• Mol file: 1224948-80-4.mol

Synonyms:1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-trans-1,4-diol

Chemical Property of 1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-trans-1,4-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-trans-1,4-diol

There total 6 articles about 1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-trans-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

4-hydroxy-4-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)cyclohexan-1-one (1224948-77-9) + (trifluoromethyl)trimethylsilane (81290-20-2) → 1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-trans-1,4-diol (1224948-80-4) + 1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-cis-1,4-diol (1224948-81-5)

Guidance literature:

4-hydroxy-4-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)cyclohexan-1-one; (trifluoromethyl)trimethylsilane; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.166667h;

With tetrabutyl ammonium fluoride; water; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

1,4-dioxaspiro<4,5>decane-8-carboxamide (30482-24-7) → 1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-trans-1,4-diol (1224948-80-4) + 1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-cis-1,4-diol (1224948-81-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: Lawessons reagent / toluene / 1 h / 100 °C

2.1: acetonitrile / 4 h / 20 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

3.2: -78 - 20 °C

4.1: hydrogenchloride; water / tetrahydrofuran / 14 h / 0 - 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

5.2: 0.5 h / 20 °C

With Lawessons reagent; hydrogenchloride; n-butyllithium; tetrabutyl ammonium fluoride; water; In tetrahydrofuran; hexane; toluene; acetonitrile;

Reference yield:

cyclohexanone-4-carboxylic acid ethyleneacetal (66500-55-8) → 1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-trans-1,4-diol (1224948-80-4) + 1-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)-4-(trifluoromethyl)cyclohexan-cis-1,4-diol (1224948-81-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: triethylamine; propoxycarbonyl chloride / tetrahydrofuran / 1.5 h / 0 - 20 °C

1.2: 1 h / 20 °C

2.1: Lawessons reagent / toluene / 1 h / 100 °C

3.1: acetonitrile / 4 h / 20 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

4.2: -78 - 20 °C

5.1: hydrogenchloride; water / tetrahydrofuran / 14 h / 0 - 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

6.2: 0.5 h / 20 °C

With Lawessons reagent; hydrogenchloride; n-butyllithium; tetrabutyl ammonium fluoride; water; triethylamine; propoxycarbonyl chloride; In tetrahydrofuran; hexane; toluene; acetonitrile;

upstream raw materials:

4-hydroxy-4-(4-(4-methoxyphenyl)-5-(p-tolyl)thiazol-2-yl)cyclohexan-1-one

(trifluoromethyl)trimethylsilane

1,4-dioxaspiro<4,5>decane-8-carboxamide

cyclohexanone-4-carboxylic acid ethyleneacetal