{3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-((S)-2-methyl-piperazin-1-yl)-methanone

Base Information

Chemical Name:{3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-((S)-2-methyl-piperazin-1-yl)-methanone
CAS No.:1431542-44-7
Molecular Formula:C₃₁H₃₃N₅O₄
Molecular Weight:539.634
Hs Code.:

Synonyms:{3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-((S)-2-methyl-piperazin-1-yl)-methanone

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Chemical Property of {3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-((S)-2-methyl-piperazin-1-yl)-methanone

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Technology Process of {3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-((S)-2-methyl-piperazin-1-yl)-methanone

There total 6 articles about {3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-((S)-2-methyl-piperazin-1-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431542-42-5
3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-benzoic acid

: 147081-29-6
(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

: 1431542-44-7
{3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-((S)-2-methyl-piperazin-1-yl)-methanone

Guidance literature:: 3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-benzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.333333h;

(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1431542-43-6
3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-benzoic acid ethyl ester

: 1431542-44-7
{3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-((S)-2-methyl-piperazin-1-yl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 4 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.33 h / 20 °C

2.2: 2 h / 20 °C

With lithium hydroxide monohydrate; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;

Reference yield:

: 1431542-29-8
3-(6-bromo-quinazolin-4-yl)-benzoic acid ethyl ester

: 1431542-44-7
{3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-((S)-2-methyl-piperazin-1-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 0.25 h / 120 °C / Microwave irradiation; Inert atmosphere

2.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 4 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.33 h / 20 °C

3.2: 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; water; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water;