{(R)-2-hydroxy-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}carbamic acid t-butyl ester

Base Information

Chemical Name:{(R)-2-hydroxy-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}carbamic acid t-butyl ester
CAS No.:1286280-51-0
Molecular Formula:C₁₈H₂₉NO₄
Molecular Weight:323.433
Hs Code.:

Synonyms:{(R)-2-hydroxy-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}carbamic acid t-butyl ester

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Chemical Property of {(R)-2-hydroxy-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}carbamic acid t-butyl ester

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Technology Process of {(R)-2-hydroxy-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}carbamic acid t-butyl ester

There total 10 articles about {(R)-2-hydroxy-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}carbamic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1286280-77-0
methyl (2R)-2-{[(tert-butoxy)carbonyl]amino}-2-{4-[(2S)-2-methylbutoxy]phenyl}acetate

: 1286280-51-0
{(R)-2-hydroxy-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}carbamic acid t-butyl ester

Guidance literature:: methyl (2R)-2-{[(tert-butoxy)carbonyl]amino}-2-{4-[(2S)-2-methylbutoxy]phenyl}acetate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

With potassium hydroxide; In tetrahydrofuran; water; ethyl acetate; for 1h;

Reference yield:

: 534-00-9
(S)-2-methylbutyl bromide

: 691889-35-7
(R)-N-(t-butoxycarbonyl)-4-(t-butyldimethylsiloxy)phenylglycinol

: 1286280-51-0
{(R)-2-hydroxy-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}carbamic acid t-butyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃;

Reference yield:

: 143323-49-3,141518-55-0
(R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate

: 1286280-51-0
{(R)-2-hydroxy-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}carbamic acid t-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 20 °C

2.2: 1 h

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;