tert-butyl (R)-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-(4-((S)-2-methylbutoxy)phenyl)ethylcarbamate

Base Information

Chemical Name:tert-butyl (R)-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-(4-((S)-2-methylbutoxy)phenyl)ethylcarbamate
CAS No.:1286280-78-1
Molecular Formula:C₂₆H₃₂N₂O₅
Molecular Weight:452.55
Hs Code.:

Synonyms:tert-butyl (R)-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-(4-((S)-2-methylbutoxy)phenyl)ethylcarbamate

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Chemical Property of tert-butyl (R)-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-(4-((S)-2-methylbutoxy)phenyl)ethylcarbamate

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Technology Process of tert-butyl (R)-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-(4-((S)-2-methylbutoxy)phenyl)ethylcarbamate

There total 10 articles about tert-butyl (R)-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-(4-((S)-2-methylbutoxy)phenyl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 136918-14-4,85-41-6
phthalimide

: 1286280-51-0
{(R)-2-hydroxy-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}carbamic acid t-butyl ester

: 1286280-78-1
tert-butyl (R)-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-(4-((S)-2-methylbutoxy)phenyl)ethylcarbamate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; at 0 - 20 ℃;

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 1286280-78-1
tert-butyl (R)-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-(4-((S)-2-methylbutoxy)phenyl)ethylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C

2.1: sodium hydroxide; tert-butylhypochlorite / water; propan-1-ol / 0.08 h / 20 °C

2.2: 0.1 h / Cooling with ice

2.3: 1.5 h / 0 °C

3.1: hydrogen / palladium on carbon / dichloromethane; ethanol / 20 °C / 760.05 Torr

4.1: caesium carbonate / N,N-dimethyl-formamide / 70 °C

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

With n-butyllithium; tert-butylhypochlorite; di-isopropyl azodicarboxylate; hydrogen; caesium carbonate; triphenylphosphine; sodium hydroxide; palladium on carbon; In tetrahydrofuran; propan-1-ol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 5.1: Mitsunobu reaction;

Reference yield:

: 36438-64-9
p-benzyloxystyrene

: 1286280-78-1
tert-butyl (R)-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-(4-((S)-2-methylbutoxy)phenyl)ethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; tert-butylhypochlorite / water; propan-1-ol / 0.08 h / 20 °C

1.2: 0.1 h / Cooling with ice

1.3: 1.5 h / 0 °C

2.1: hydrogen / palladium on carbon / dichloromethane; ethanol / 20 °C / 760.05 Torr

3.1: caesium carbonate / N,N-dimethyl-formamide / 70 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

With tert-butylhypochlorite; di-isopropyl azodicarboxylate; hydrogen; caesium carbonate; triphenylphosphine; sodium hydroxide; palladium on carbon; In tetrahydrofuran; propan-1-ol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 4.1: Mitsunobu reaction;