2-[(2R)-2-(4-nitrophenyl)propyl]isoindoline-1,3-dione

Base Information

Chemical Name:2-[(2R)-2-(4-nitrophenyl)propyl]isoindoline-1,3-dione
CAS No.:376594-70-6
Molecular Formula:C₁₇H₁₄N₂O₄
Molecular Weight:310.309
Hs Code.:
DSSTox Substance ID:DTXSID901187814

Synonyms:SCHEMBL6556194;2-[(2R)-2-(4-nitrophenyl)propyl]isoindoline-1,3-dione;GXNDOTNRLKMIGC-NSHDSACASA-N;DTXSID901187814;376594-70-6;((2R)-2-(4-nitrophenyl)propyl]isoindoline-1,3-dione;2-[(2R)-2-(4-Nitrophenyl)propyl]-1H-isoindole-1,3(2H)-dione

Suppliers and Price of 2-[(2R)-2-(4-nitrophenyl)propyl]isoindoline-1,3-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 0 raw suppliers

Chemical Property of 2-[(2R)-2-(4-nitrophenyl)propyl]isoindoline-1,3-dione

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:310.09535693
Heavy Atom Count:23
Complexity:469

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(CN1C(=O)C2=CC=CC=C2C1=O)C3=CC=C(C=C3)[N+](=O)[O-]
Isomeric SMILES:C[C@@H](CN1C(=O)C2=CC=CC=C2C1=O)C3=CC=C(C=C3)[N+](=O)[O-]

Technology Process of 2-[(2R)-2-(4-nitrophenyl)propyl]isoindoline-1,3-dione

There total 7 articles about 2-[(2R)-2-(4-nitrophenyl)propyl]isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 136918-14-4,85-41-6
phthalimide

: 185130-37-4
R-2-(4-nitrophenyl)-1-propanol

: 376594-70-6
N-(R-2-(4-nitrophenyl)-1-propyl)phthalimide

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1002/jlcr.899

Reference yield:

: 19910-33-9
2-(4-nitrophenyl)propanoic acid

: 376594-70-6
N-(R-2-(4-nitrophenyl)-1-propyl)phthalimide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / -78 - 5 °C

2: 24 percent / triphenylmethane; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - -20 °C

3: 91 percent / sodium borohydride / tetrahydrofuran; H₂O / 3 h / 20 °C

4: 88 percent / triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 18 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; triphenylmethane; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; water; 4: Mitsunobu reaction;
DOI:10.1002/jlcr.899

Reference yield:

: 104-03-0
4-nitrobenzeneacetic acid

: 376594-70-6
N-(R-2-(4-nitrophenyl)-1-propyl)phthalimide

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / pyridine; cyanuric fluoride / acetonitrile / 3.5 h / 20 °C

2: 34 percent / triphenylmethane; n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3: 33 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / -70 - 20 °C

4: 91 percent / sodium borohydride / tetrahydrofuran; H₂O / 3 h / 20 °C

5: 88 percent / triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 18 h / 20 °C

With pyridine; sodium tetrahydroborate; n-butyllithium; trifluoro-[1,3,5]triazine; triphenylmethane; sodium hexamethyldisilazane; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; water; toluene; acetonitrile; 5: Mitsunobu reaction;
DOI:10.1002/jlcr.899