Lactose

Base Information

• Chemical Name: Lactose
• CAS No.: 63-42-3
• Deprecated CAS: 1336-90-9,35396-14-6,73824-63-2,89466-76-2,200734-90-3,36570-80-6,1065027-17-9,396716-09-9
• Molecular Formula: C12H22O11
• Molecular Weight: 342.3
• Hs Code.: 17021100
• UNII: 3SY5LH9PMK
• Nikkaji Number: J353.435I
• Wikidata: Q76149967
• Mol file: 63-42-3.mol

Synonyms:4-O-beta-D-Galactopyranosyl-D-glucose;D-Glucose, 4-O-beta-D-galactopyranosyl-;Galactinum;Fast-flo Lactose;

Chemical Property of Lactose

Chemical Property:

• Appearance/Colour: white crystals or powder
• Vapor Pressure: 1.08E-20mmHg at 25°C
• Melting Point: 222.8 °C
• Refractive Index: 1.652
• Boiling Point: 667.9 °C at 760 mmHg
• PKA: 12.39±0.20(Predicted)
• Flash Point: 357.8 °C
• PSA: 197.37000
• Density: 1.76 g/cm³
• LogP: -5.55460
• Storage Temp.: 2-8°C
• Solubility.: Freely but slowly soluble in water, practically insoluble in ethanol (96 per cent).
• Water Solubility.: 5-10 g/100 mL at 20 ºC
• XLogP3: -5
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 8
• Exact Mass: 342.11621151
• Heavy Atom Count: 23
• Complexity: 367

Purity/Quality:

99% ^*data from raw suppliers

Lactose, anhydrous ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(C1C(C(C(C(O1)OC(C(CO)O)C(C(C=O)O)O)O)O)O)O
• Isomeric SMILES: C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O[C@H]([C@@H](CO)O)[C@@H]([C@H](C=O)O)O)O)O)O)O
• Uses: A disaccharide sugar present in milk. Lactose is a disaccharide carbohydrate that occurs in mammalian milk except that of the whale and the hippopotamus. it is princi- pally obtained as a cows’ milk derivative. it is also termed milk sugar and it is a reducing sugar consisting of glucose and galactose. its most common commercial form is alpha-monohydrate, with the beta-anhydride form available to a lesser extent. all forms in solution will equilibrate to a beta:alpha ratio of 62.25:37.75 at 0°c. it is about one-sixth as sweet as sugar and is less soluble. it functions as a flow agent, humectant, crystallization control agent, and sweetener. it is used in baked goods for flavor, browning, and tenderizing and in dry mixes as an anticaking agent. D-Lactose is used for the culture of lactic acid metabolizing bacteria, lactic acid bacteria. D-Lactose is used to identify and characterized galectins.

Technology Process of Lactose

There total 8 articles about Lactose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

meso-erythritol (909878-64-4,10030-58-7,188346-77-2,149-32-6) + L-Tartaric acid (87-69-4,138508-61-9) → (+)-proto-quercitol (488-73-3) + Sucrose (57-50-1) + D-(+)-lactose (63-42-3)

Guidance literature:

Reference yield:

acetic acid (64-19-7,77671-22-8) + 2′-fucosyllactose (41263-94-9) → L-Fucose (2438-80-4,478518-52-4) + D-(+)-lactose (63-42-3)

Guidance literature:

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + 2′-fucosyllactose (41263-94-9) → L-Fucose (2438-80-4,478518-52-4) + D-(+)-lactose (63-42-3)

Guidance literature:

upstream raw materials:

β-D-glucose

(E)-3-Ureido-but-2-enoic acid ethyl ester

acetic acid

2′-fucosyllactose

Downstream raw materials:

lactosucrose

lactose-isonicotinoylhydrazone

O¹,O²,O³,O⁶-Tetrakis-(2-methoxy-phenoxycarbonyl)-O⁴-[tetrakis-O-(2-methoxy-phenoxycarbonyl)-β-D-galactopyranosyl]-ξ-D-glucopyranose

2,3,6,2',3',4',6'-hepta-O-acetyl-lactosyl bromide

Refernces

Total synthesis of sulfated Le(x) pentaosyl ceramide

10.1016/0008-6215(94)00264-9

The research details the first total synthesis of sulfated Le" pentaosyl ceramide, a significant endeavor due to the biological importance of these compounds in cell-adhesion processes, particularly in mediating the binding of leucocytes to endothelial cells and platelets. The study aimed to provide an efficient chemical synthesis method for these ligands, which are recognized by L-selectin. The synthesis process involved a series of complex glycosylation reactions using compounds derived from D-galactose, 2-amino-2-deoxy-D-glucose, rA.tcose, and lactose, among others. Key chemicals used in the synthesis included ceramide derivative 4, glycopentaosyl donor 3, and various protecting and deprotecting agents such as levulinic anhydride, hydrazine hydrate, and NaOH. The successful synthesis was confirmed through various spectroscopic techniques, and the final products, sulfated Le" pentaosyl ceramide 1 and 2, were obtained after a series of transformations and deprotection steps. The study concluded with the achievement of a stereo-controlled synthesis of the sulfated Le" pentaosylceramides, providing a foundation for further chemical and biological scrutiny of these compounds.