Thioacetic acid S-[(2S,3S,4R,5R)-4-hydroxy-3-[2-(4-methoxy-phenoxy)-ethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Base Information

Chemical Name:Thioacetic acid S-[(2S,3S,4R,5R)-4-hydroxy-3-[2-(4-methoxy-phenoxy)-ethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester
CAS No.:144944-91-2
Molecular Formula:C₂₁H₂₆N₂O₇S
Molecular Weight:450.513
Hs Code.:

Thioacetic acid S-[(2S,3S,4R,5R)-4-hydroxy-3-[2-(4-methoxy-phenoxy)-ethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Synonyms:Thioacetic acid S-[(2S,3S,4R,5R)-4-hydroxy-3-[2-(4-methoxy-phenoxy)-ethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

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Chemical Property of Thioacetic acid S-[(2S,3S,4R,5R)-4-hydroxy-3-[2-(4-methoxy-phenoxy)-ethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

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Technology Process of Thioacetic acid S-[(2S,3S,4R,5R)-4-hydroxy-3-[2-(4-methoxy-phenoxy)-ethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

There total 7 articles about Thioacetic acid S-[(2S,3S,4R,5R)-4-hydroxy-3-[2-(4-methoxy-phenoxy)-ethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 144944-86-5
3'-deoxy-3'-C-(2-hydroxyethyl)-2-O-para-methoxyphenyl-(β-D-ribofuranosyl)thymine

: 507-09-5
tiolacetic acid

: 144944-91-2
Thioacetic acid S-[(2S,3S,4R,5R)-4-hydroxy-3-[2-(4-methoxy-phenoxy)-ethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;

Reference yield:

: 58399-76-1
3-Deoxy-3-C-(2'-hydroxyethyl)-1,2-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranose

: 144944-91-2
Thioacetic acid S-[(2S,3S,4R,5R)-4-hydroxy-3-[2-(4-methoxy-phenoxy)-ethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 0.33 h / Heating

2: 69 percent / 2.) camphorsulfonic acid / acetic acid / 70 °C / 1.) 15 min, 2.) 12 min

3: 91 percent / trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 6 h / Heating

4: 100 percent / methanolic ammonia / 10 h / Ambient temperature

5: 85 percent / diisopropyl azodicarboxylate, PPh₃ / tetrahydrofuran

With di-isopropyl azodicarboxylate; camphor-10-sulfonic acid; ammonia; triphenylphosphine; diethylazodicarboxylate; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane; acetic acid;

Reference yield:

: 150-76-5
4-methoxy-phenol

: 144944-91-2
Thioacetic acid S-[(2S,3S,4R,5R)-4-hydroxy-3-[2-(4-methoxy-phenoxy)-ethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 0.33 h / Heating

2: 69 percent / 2.) camphorsulfonic acid / acetic acid / 70 °C / 1.) 15 min, 2.) 12 min

3: 91 percent / trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 6 h / Heating

4: 100 percent / methanolic ammonia / 10 h / Ambient temperature

5: 85 percent / diisopropyl azodicarboxylate, PPh₃ / tetrahydrofuran

With di-isopropyl azodicarboxylate; camphor-10-sulfonic acid; ammonia; triphenylphosphine; diethylazodicarboxylate; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane; acetic acid;