4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-[(E)-2-cyano-2-ethoxyethenyl]-2,2-dimethylcyclopropane carboxylate

Base Information

Chemical Name:4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-[(E)-2-cyano-2-ethoxyethenyl]-2,2-dimethylcyclopropane carboxylate
CAS No.:1425039-41-3
Molecular Formula:C₂₀H₂₁F₄NO₄
Molecular Weight:415.385
Hs Code.:

Synonyms:4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-[(E)-2-cyano-2-ethoxyethenyl]-2,2-dimethylcyclopropane carboxylate

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Chemical Property of 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-[(E)-2-cyano-2-ethoxyethenyl]-2,2-dimethylcyclopropane carboxylate

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Technology Process of 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-[(E)-2-cyano-2-ethoxyethenyl]-2,2-dimethylcyclopropane carboxylate

There total 3 articles about 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-[(E)-2-cyano-2-ethoxyethenyl]-2,2-dimethylcyclopropane carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83282-91-1
2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl alcohol

: 1425039-47-9
(1R)-trans-3-[(1E)-2-cyano-2-ethoxyethenyl]-2,2-dimethylcyclopropanecarboxylic acid

: 1425039-41-3
4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-[(E)-2-cyano-2-ethoxyethenyl]-2,2-dimethylcyclopropane carboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform; at 20 ℃; for 12h;

Reference yield:

: 27335-33-7
methyl (1R,3R)-3-formyl-2,2-dimethylcyclopropanecarboxylate

: 1425039-41-3
4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-[(E)-2-cyano-2-ethoxyethenyl]-2,2-dimethylcyclopropane carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.67 h / 25 °C / Inert atmosphere; Cooling with ice

1.2: 25 °C

2.1: potassium hydroxide; water / methanol / 12 h / 20 °C

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 12 h / 20 °C

With dmap; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In tetrahydrofuran; methanol; chloroform; mineral oil;

Reference yield:

: 1425039-58-2
methyl (1R)-trans-3-[(1E)-2-cyano-2-ethoxyethenyl]-2,2-dimethylcyclopropane carboxylate

: 1425039-41-3
4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-[(E)-2-cyano-2-ethoxyethenyl]-2,2-dimethylcyclopropane carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide; water / methanol / 12 h / 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 12 h / 20 °C

With dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In methanol; chloroform;