N-(2-(difluoromethoxy)-5-methyl-phenyl)-4-methoxy-3-(1-methyl-pyrrolidin-3-yl)-benzenesulfonamide hydrochloride

Base Information

Chemical Name:N-(2-(difluoromethoxy)-5-methyl-phenyl)-4-methoxy-3-(1-methyl-pyrrolidin-3-yl)-benzenesulfonamide hydrochloride
CAS No.:1374646-76-0
Molecular Formula:C₂₀H₂₄F₂N₂O₄S*ClH
Molecular Weight:462.945
Hs Code.:

Synonyms:N-(2-(difluoromethoxy)-5-methyl-phenyl)-4-methoxy-3-(1-methyl-pyrrolidin-3-yl)-benzenesulfonamide hydrochloride

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Chemical Property of N-(2-(difluoromethoxy)-5-methyl-phenyl)-4-methoxy-3-(1-methyl-pyrrolidin-3-yl)-benzenesulfonamide hydrochloride

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Technology Process of N-(2-(difluoromethoxy)-5-methyl-phenyl)-4-methoxy-3-(1-methyl-pyrrolidin-3-yl)-benzenesulfonamide hydrochloride

There total 4 articles about N-(2-(difluoromethoxy)-5-methyl-phenyl)-4-methoxy-3-(1-methyl-pyrrolidin-3-yl)-benzenesulfonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1374646-75-9
N-(2-(difluoromethoxy)-5-methylphenyl)-4-methoxy-3-pyrrolidin-3-yl-benzenesulfonamide hydrochloride

: 1374646-76-0
N-(2-(difluoromethoxy)-5-methyl-phenyl)-4-methoxy-3-(1-methyl-pyrrolidin-3-yl)-benzenesulfonamide hydrochloride

Guidance literature:: formaldehyd; N-(2-(difluoromethoxy)-5-methylphenyl)-4-methoxy-3-pyrrolidin-3-yl-benzenesulfonamide hydrochloride; With hydrogenchloride; sodium cyanoborohydride; In water; acetonitrile; at 20 ℃; for 18h; pH=2;

With hydrogenchloride; In diethyl ether;

Reference yield:

: 91246-24-1
3-(2-Methoxyphenyl)pyrrolidine

: 1374646-76-0
N-(2-(difluoromethoxy)-5-methyl-phenyl)-4-methoxy-3-(1-methyl-pyrrolidin-3-yl)-benzenesulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane / 18 h / -20 - 20 °C

2: chlorosulfonic acid / dichloromethane / 19 h / -5 - 20 °C

3: pyridine / 18 h / 20 °C

4: water; sodium hydroxide / methanol / 2 h / 20 °C

5: hydrogenchloride; sodium cyanoborohydride / water; acetonitrile / 18 h / 20 °C / pH 2

With pyridine; hydrogenchloride; chlorosulfonic acid; water; sodium cyanoborohydride; sodium hydroxide; In methanol; dichloromethane; water; acetonitrile;

Reference yield:

: 648901-36-4
2,2,2-trifluoro-1-[3-(2-methoxy-phenyl)-pyrrolidin-1-yl]-ethanone

: 1374646-76-0
N-(2-(difluoromethoxy)-5-methyl-phenyl)-4-methoxy-3-(1-methyl-pyrrolidin-3-yl)-benzenesulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: chlorosulfonic acid / dichloromethane / 19 h / -5 - 20 °C

2: pyridine / 18 h / 20 °C

3: water; sodium hydroxide / methanol / 2 h / 20 °C

4: hydrogenchloride; sodium cyanoborohydride / water; acetonitrile / 18 h / 20 °C / pH 2

With pyridine; hydrogenchloride; chlorosulfonic acid; water; sodium cyanoborohydride; sodium hydroxide; In methanol; dichloromethane; water; acetonitrile;