5-[(4-Methylphenyl)methylene]-2-thioxo-4-imidazolidinone

Base Information

Chemical Name:5-[(4-Methylphenyl)methylene]-2-thioxo-4-imidazolidinone
CAS No.:51009-66-6
Molecular Formula:C₁₁H₁₀N₂OS
Molecular Weight:218.279
Hs Code.:
DSSTox Substance ID:DTXSID701201278

Synonyms:DTXSID701201278;51009-66-6;NCI60_030273;5-[(4-Methylphenyl)methylene]-2-thioxo-4-imidazolidinone

Suppliers and Price of 5-[(4-Methylphenyl)methylene]-2-thioxo-4-imidazolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 5-[(4-Methylphenyl)methylene]-2-thioxo-4-imidazolidinone

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:218.05138412
Heavy Atom Count:15
Complexity:317

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C=C2C(=O)NC(=S)N2

Technology Process of 5-[(4-Methylphenyl)methylene]-2-thioxo-4-imidazolidinone

There total 4 articles about 5-[(4-Methylphenyl)methylene]-2-thioxo-4-imidazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 503-87-7
2-thiohydantoin

: 18300-87-3
ethyl 2-cyano-3-p-tolylacrylate

: 51009-66-6
5-(4-methylbenzylidene)-2-thioxoimidazolidin-4-one

Guidance literature:: With pyridine; In ethanol; at 90 ℃; for 8h;

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

: 51009-66-6,110830-16-5
5-(4-methylbenzylidene)-2-thioxoimidazolidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / 0.75 h / 140 °C / Microwave irradiation; Green chemistry

2: dimethylsulfoxide-d6 / UV-irradiation

With sodium hydrogencarbonate; In dimethylsulfoxide-d6; 1: |Knoevenagel Condensation;
DOI:10.1002/cmdc.202000048