α-Cyano-4-methylbenzeneacrylic acid ethyl ester

Base Information

• Chemical Name: α-Cyano-4-methylbenzeneacrylic acid ethyl ester
• CAS No.: 18300-87-3
• Molecular Formula: C13H13NO2
• Molecular Weight: 215.252
• Mol file: 18300-87-3.mol

Synonyms:ethyl 2-cyano-3-p-tolylacrylate;ethyl 2-cyano-3-(4-methylphenyl)-prop-2-enecarboxylate;2-cyano-3-p-tolyl-acrylic acid ethyl ester;2-Propenoic acid,2-cyano-3-(3,4,5-trimethoxyphenyl)-,ethyl ester;2-Cyan-3-p-tolyl-acrylsaeure-aethylester;ethyl 2-cyano-3-(3,4,5-trimethoxyphenyl)acrylate;2-cyano-3-(3,4,5-trimethoxyphenyl)acrylic acid ethyl ester;

Chemical Property of α-Cyano-4-methylbenzeneacrylic acid ethyl ester

Chemical Property:

• PSA: 50.09000
• LogP: 2.46508

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-Cyano-3-(4-methylphenyl)acrylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of α-Cyano-4-methylbenzeneacrylic acid ethyl ester

There total 16 articles about α-Cyano-4-methylbenzeneacrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methylbenzaldehyde dimethylacetal (3395-83-3) + ethyl 2-cyanoacetate (105-56-6) → ethyl 2-cyano-3-p-tolylacrylate (18300-87-3)

Guidance literature:

With MS-SO₃H(at)MS(at)MS-NH₂; In toluene; at 80 ℃; for 0.5h; Reagent/catalyst;

DOI:10.1039/c3ta13185h

Reference yield: 99.0%

4-methyl-benzaldehyde (104-87-0) + ethyl 2-cyanoacetate (105-56-6) → ethyl 2-cyano-3-p-tolylacrylate (18300-87-3)

Guidance literature:

With Zr(IV)-salen-MCM-41; In water; at 35 ℃; for 6h;

DOI:10.1016/S1872-2067(15)60968-8

Reference yield: 99.0%

dimethyl 2-(4-methylbenzylidene)malonate (59832-45-0) + ethyl 2-cyanoacetate (105-56-6) → ethyl 2-cyano-3-p-tolylacrylate (18300-87-3)

Guidance literature:

With recovered palladium catalyst; In ethanol; at 20 ℃; for 18h; Green chemistry;

DOI:10.1039/c3gc40991k

upstream raw materials:

ethanol

2-cyano-3-(p-tolyl)acrylic acid

4-methyl-benzaldehyde

ethyl 2-cyanoacetate

Downstream raw materials:

5-amino-2-(4-methyl-benzylidene)-3-oxo-7-p-tolyl-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-6,8-dicarboxylic acid diethyl ester

4-methyl-benzaldehyde

2-Oxo-4-p-tolyl-1,2,5,6,7,8-hexahydro-quinoline-3-carbonitrile

2-Oxo-4-p-tolyl-7-[1-p-tolyl-meth-(Z)-ylidene]-2,5,6,7-tetrahydro-1H-[1]pyrindine-3-carbonitrile