(1R,4S,5R,8R)-8-Methyl-4-phenyl-4-phenylsulfanylmethyl-2,3-dioxa-bicyclo[3.3.1]nonan-8-ol

Base Information

Chemical Name:(1R,4S,5R,8R)-8-Methyl-4-phenyl-4-phenylsulfanylmethyl-2,3-dioxa-bicyclo[3.3.1]nonan-8-ol
CAS No.:779358-28-0
Molecular Formula:C₂₁H₂₄O₃S
Molecular Weight:356.486
Hs Code.:

Synonyms:(1R,4S,5R,8R)-8-Methyl-4-phenyl-4-phenylsulfanylmethyl-2,3-dioxa-bicyclo[3.3.1]nonan-8-ol

Suppliers and Price of (1R,4S,5R,8R)-8-Methyl-4-phenyl-4-phenylsulfanylmethyl-2,3-dioxa-bicyclo[3.3.1]nonan-8-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,4S,5R,8R)-8-Methyl-4-phenyl-4-phenylsulfanylmethyl-2,3-dioxa-bicyclo[3.3.1]nonan-8-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1R,4S,5R,8R)-8-Methyl-4-phenyl-4-phenylsulfanylmethyl-2,3-dioxa-bicyclo[3.3.1]nonan-8-ol

There total 5 articles about (1R,4S,5R,8R)-8-Methyl-4-phenyl-4-phenylsulfanylmethyl-2,3-dioxa-bicyclo[3.3.1]nonan-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 779358-27-9
(1R,5R,8R)-8-Methyl-4-phenyl-4-phenylsulfanylmethyl-2,3-dioxa-bicyclo[3.3.1]non-8-yl-hydroperoxide

: 779358-28-0
(1R,4S,5R,8R)-8-Methyl-4-phenyl-4-phenylsulfanylmethyl-2,3-dioxa-bicyclo[3.3.1]nonan-8-ol

: (1R,4R,5R,8R)-8-Methyl-4-phenyl-4-phenylsulfanylmethyl-2,3-dioxa-bicyclo[3.3.1]nonan-8-ol

Guidance literature:: With triphenylphosphine; In dichloromethane; acetonitrile; at 0 - 20 ℃;
DOI:10.1002/anie.200453859

Reference yield:

: 6090-09-1,57072-59-0,70286-20-3,54973-16-9
methyl-[(1R)-4-methylcyclohex-3-enyl]ketone

: 779358-28-0
(1R,4S,5R,8R)-8-Methyl-4-phenyl-4-phenylsulfanylmethyl-2,3-dioxa-bicyclo[3.3.1]nonan-8-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / KHMDS / tetrahydrofuran / -78 - -40 °C

2: 75 percent / Ni(acac)2 / diethyl ether / 20 °C

3: O₂; azobis(isobutyronitrile) / acetonitrile / 0.5 h / 0 °C / Irradiation

4: Ph₃P / acetonitrile; CH₂Cl₂ / 0 - 20 °C

With bis(acetylacetonate)nickel(II); 2,2'-azobis(isobutyronitrile); oxygen; potassium hexamethylsilazane; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1002/anie.200453859

Reference yield:

: 4680-24-4
cis-(R)-limonene oxide

: 779358-28-0
(1R,4S,5R,8R)-8-Methyl-4-phenyl-4-phenylsulfanylmethyl-2,3-dioxa-bicyclo[3.3.1]nonan-8-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: O₃ / CH₂Cl₂ / -78 °C

1.2: 50 percent / Zn; acetic acid; sodium iodide / sodium acetate

2.1: 64 percent / KHMDS / tetrahydrofuran / -78 - -40 °C

3.1: 75 percent / Ni(acac)2 / diethyl ether / 20 °C

4.1: O₂; azobis(isobutyronitrile) / acetonitrile / 0.5 h / 0 °C / Irradiation

5.1: Ph₃P / acetonitrile; CH₂Cl₂ / 0 - 20 °C

With bis(acetylacetonate)nickel(II); 2,2'-azobis(isobutyronitrile); oxygen; potassium hexamethylsilazane; ozone; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1002/anie.200453859