4-Chloro-6-methoxycarbonylamino-pyridine-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 4-Chloro-6-methoxycarbonylamino-pyridine-2-carboxylic acid methyl ester
• CAS No.: 121572-38-1
• Molecular Formula: C₉H₉ClN₂O₄
• Molecular Weight: 244.634
• Mol file: 121572-38-1.mol

Synonyms:4-Chloro-6-methoxycarbonylamino-pyridine-2-carboxylic acid methyl ester

Chemical Property of 4-Chloro-6-methoxycarbonylamino-pyridine-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-Chloro-6-methoxycarbonylamino-pyridine-2-carboxylic acid methyl ester

There total 3 articles about 4-Chloro-6-methoxycarbonylamino-pyridine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

methanol (67-56-1) + 4-chloropyridine-2,6-diylcarboxylic acid diazide (121572-36-9) → 4-Chloro-6-methoxycarbonylamino-pyridine-2-carboxylic acid methyl ester (121572-38-1) + dimethyl (4-chloropyridine-2,6-diyl)bis (121572-37-0)

Guidance literature:

for 8h; Heating;

DOI:10.1021/jm00130a023

Reference yield:

(4-chloropyridine-2,6-diyl)bisdihydrazide (98276-29-0) → 4-Chloro-6-methoxycarbonylamino-pyridine-2-carboxylic acid methyl ester (121572-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaNO₂, 10percent HCl / H₂O / 1 h / Ambient temperature

2: 8 h / Heating

With hydrogenchloride; sodium nitrite; In water;

DOI:10.1021/jm00130a023

Reference yield:

methanol (67-56-1) + (6-Azidocarbonyl-4-chloro-pyridin-2-yl)-carbamic acid methyl ester (121572-40-5) → 4-Chloro-6-methoxycarbonylamino-pyridine-2-carboxylic acid methyl ester (121572-38-1) + dimethyl (4-chloropyridine-2,6-diyl)bis (121572-37-0)

Guidance literature:

for 8h; Yield given; Heating;

DOI:10.1021/jm00130a023

upstream raw materials:

methanol

(6-Azidocarbonyl-4-chloro-pyridin-2-yl)-carbamic acid methyl ester

4-chloropyridine-2,6-diylcarboxylic acid diazide

(4-chloropyridine-2,6-diyl)bisdihydrazide