2-[2-phenyl-2-oxoethyl]-5,6,7,8-tetrahydroisoquinolinium bromide

Base Information

• Chemical Name: 2-[2-phenyl-2-oxoethyl]-5,6,7,8-tetrahydroisoquinolinium bromide
• CAS No.: 109943-57-9
• Molecular Formula: Br*C₁₇H₁₈NO
• Molecular Weight: 332.24
• Mol file: 109943-57-9.mol

Synonyms:2-[2-phenyl-2-oxoethyl]-5,6,7,8-tetrahydroisoquinolinium bromide

Chemical Property of 2-[2-phenyl-2-oxoethyl]-5,6,7,8-tetrahydroisoquinolinium bromide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-[2-phenyl-2-oxoethyl]-5,6,7,8-tetrahydroisoquinolinium bromide

There total 1 articles about 2-[2-phenyl-2-oxoethyl]-5,6,7,8-tetrahydroisoquinolinium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5,6,7,8-tetrahydroisoquinoline (36556-06-6) + α-bromoacetophenone (70-11-1) → 2-[2-phenyl-2-oxoethyl]-5,6,7,8-tetrahydroisoquinolinium bromide (109943-57-9)

Guidance literature:

In acetone; at 20 ℃; for 6h;

DOI:10.1016/j.tetlet.2014.08.054

Reference yield: 50.0%

2-[2-phenyl-2-oxoethyl]-5,6,7,8-tetrahydroisoquinolinium bromide (109943-57-9) + dimethyl acetylenedicarboxylate (762-42-5) → dimethyl 3-benzoyl-7,8,9,10-tetrahydropyrrolo[2,1-a]isoquinoline-1,2-dicarboxylate

Guidance literature:

With triethylamine; In dichloromethane; for 8h;

DOI:10.1016/j.tetlet.2014.08.054

Reference yield: 45.0%

2-[2-phenyl-2-oxoethyl]-5,6,7,8-tetrahydroisoquinolinium bromide (109943-57-9) + propynoic acid methyl ester (922-67-8) → methyl 3-benzoyl-7,8,9,10-tetrahydropyrrolo[2,1-a]isoquinoline-1-carboxylate

Guidance literature:

In tetrahydrofuran; for 12h; Reflux;

DOI:10.1016/j.tetlet.2014.08.054

upstream raw materials:

5,6,7,8-tetrahydroisoquinoline

α-bromoacetophenone