benzyl (S)-(1-(methoxyamino)-1-oxo-3-phenylpropan-2-yl)carbamate

Base Information

• Chemical Name: benzyl (S)-(1-(methoxyamino)-1-oxo-3-phenylpropan-2-yl)carbamate
• CAS No.: 923570-05-2
• Molecular Formula: C₁₈H₂₀N₂O₄
• Molecular Weight: 328.368
• Mol file: 923570-05-2.mol

Synonyms:benzyl (S)-(1-(methoxyamino)-1-oxo-3-phenylpropan-2-yl)carbamate

Chemical Property of benzyl (S)-(1-(methoxyamino)-1-oxo-3-phenylpropan-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (S)-(1-(methoxyamino)-1-oxo-3-phenylpropan-2-yl)carbamate

There total 2 articles about benzyl (S)-(1-(methoxyamino)-1-oxo-3-phenylpropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-Cbz-L-Phe (1161-13-3) + N-methoxylamine hydrochloride (593-56-6) → benzyl (S)-(1-(methoxyamino)-1-oxo-3-phenylpropan-2-yl)carbamate (923570-05-2)

Guidance literature:

N-Cbz-L-Phe; N-methoxylamine hydrochloride; With diisopropylamine; In dichloromethane; at 0 ℃; for 0.25h;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 8h;

DOI:10.1039/d1ob00055a

Reference yield:

O-Methylhydroxylamin (67-62-9) + N-Cbz-L-Phe (1161-13-3) → benzyl (S)-(1-(methoxyamino)-1-oxo-3-phenylpropan-2-yl)carbamate (923570-05-2)

Guidance literature:

With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1021/acs.orglett.5b00196

Reference yield: 64.0%

benzyl (S)-(1-(methoxyamino)-1-oxo-3-phenylpropan-2-yl)carbamate (923570-05-2) + 1-ethynyl-1,2-benziodoxol-3(1H)-one (1252671-79-6) → (Z)-N-(1,2-d2-1-vin-2-yl)-Cbz-L-phenylalanine-N-methoxyamide-1,2-benziodoxol-3-(1H)-one

Guidance literature:

With water-d2; potassium carbonate; In 1,2-dichloro-ethane; at 20 ℃; for 24h; stereoselective reaction; Inert atmosphere;

DOI:10.1039/d1ob00055a

upstream raw materials:

N-Cbz-L-Phe

N-methoxylamine hydrochloride

O-Methylhydroxylamin

Downstream raw materials:

((S)-1-Methoxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-carbamic acid benzyl ester

2-chloro-N-[1-((2S)-2,3-dihydroxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-(3R)-yl]-6h-thieno[2,3-b]pyrrole-5-carboxamide

2-chloro-{(3R)-1-[(2R)-2,3-dihydroxypropyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl}-6H-thieno[2,3-b]pyrrole-5-carboxamide

2-chloro-N-[1-((2S)-2,3-dihydroxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-(3S)-yl]-6h-thieno[2,3-b]pyrrole-5-carboxamide