ethyl 1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)piperidine-4-carboxylate

Base Information

Chemical Name:ethyl 1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)piperidine-4-carboxylate
CAS No.:1369872-08-1
Molecular Formula:C₂₁H₂₅F₂N₅O₃
Molecular Weight:433.458
Hs Code.:

Synonyms:ethyl 1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)piperidine-4-carboxylate

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Chemical Property of ethyl 1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)piperidine-4-carboxylate

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Technology Process of ethyl 1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)piperidine-4-carboxylate

There total 2 articles about ethyl 1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 536748-06-8
4-amino-3-fluoro-N,N-dimethylbenzamide

: 1369872-07-0
ethyl 1-(6-chloro-5-fluoropyrimidin-4-yl)piperidine-4-carboxylate

: 1369872-08-1
ethyl 1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)piperidine-4-carboxylate

Guidance literature:: With caesium carbonate; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; at 102 ℃; for 2h; Inert atmosphere;

Reference yield:

: 455-87-8
4-amino-3-fluorobenzoic acid

: 1369872-08-1
ethyl 1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / acetonitrile / 0.5 h / 0 - 20 °C

2: caesium carbonate / palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene / 1,4-dioxane / 2 h / 102 °C / Inert atmosphere

With caesium carbonate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; acetonitrile;

Reference yield: 95.0%

: 1369872-08-1
ethyl 1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)piperidine-4-carboxylate

: 1369872-11-6
1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)piperidine-4-carboxylic acid

Guidance literature:: ethyl 1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)piperidine-4-carboxylate; With triethylamine; lithium bromide; In water; acetonitrile; at 50 - 75 ℃; for 16h;

With hydrogenchloride; In water; pH=1; Cooling with ice;