3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethyl chloride

Base Information

Chemical Name:3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethyl chloride
CAS No.:1222139-52-7
Molecular Formula:C₂₃H₂₉ClN₂O₃
Molecular Weight:416.948
Hs Code.:

Synonyms:3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethyl chloride

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Chemical Property of 3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethyl chloride

Chemical Property:

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Technology Process of 3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethyl chloride

There total 6 articles about 3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74115-13-2
5-bromopyridine-3-ol

: 1222139-52-7
3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethyl chloride

Guidance literature:: Multi-step reaction with 6 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0.5 h / Cooling with ice; Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine / 16 h / Reflux; Inert atmosphere

3: potassium hydroxide / methanol; hexane / 3 h / 20 °C

4: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / hexane; ethyl acetate / 18.5 h / 20 °C / Inert atmosphere

5: platinum(IV) oxide; hydrogen / ethyl acetate / 6.25 h / 20 °C

6: 2,6-dimethylpyridine; methanesulfonyl chloride; lithium chloride / N,N-dimethyl-formamide / 20 °C

With 2,6-dimethylpyridine; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; di-isopropyl azodicarboxylate; hydrogen; methanesulfonyl chloride; triethylamine; triphenylphosphine; lithium chloride; potassium hydroxide; In tetrahydrofuran; methanol; hexane; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1222139-50-5
[3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenyl]methanol

: 1222139-52-7
3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethyl chloride

Guidance literature:: With 2,6-dimethylpyridine; methanesulfonyl chloride; lithium chloride; In N,N-dimethyl-formamide;

Reference yield:

: 186593-31-7
(S)-2-(5-bromo-pyridin-3-yloxymethyl)-azetidine-1-carboxylic acid tert-butyl ester

: 1222139-52-7
3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine / 16 h / Reflux; Inert atmosphere

2: potassium hydroxide / methanol; hexane / 3 h / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / hexane; ethyl acetate / 18.5 h / 20 °C / Inert atmosphere

4: platinum(IV) oxide; hydrogen / ethyl acetate / 6.25 h / 20 °C

5: 2,6-dimethylpyridine; methanesulfonyl chloride; lithium chloride / N,N-dimethyl-formamide / 20 °C

With 2,6-dimethylpyridine; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; methanesulfonyl chloride; triethylamine; triphenylphosphine; lithium chloride; potassium hydroxide; In methanol; hexane; ethyl acetate; N,N-dimethyl-formamide;