[3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenyl]methanol

Base Information

Chemical Name:[3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenyl]methanol
CAS No.:1222139-50-5
Molecular Formula:C₂₃H₃₀N₂O₄
Molecular Weight:398.502
Hs Code.:

Synonyms:[3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenyl]methanol

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Chemical Property of [3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenyl]methanol

Chemical Property:

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Technology Process of [3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenyl]methanol

There total 5 articles about [3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74115-13-2
5-bromopyridine-3-ol

: 1222139-50-5
[3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenyl]methanol

Guidance literature:: Multi-step reaction with 5 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0.5 h / Cooling with ice; Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine / 16 h / Reflux; Inert atmosphere

3: potassium hydroxide / methanol; hexane / 3 h / 20 °C

4: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / hexane; ethyl acetate / 18.5 h / 20 °C / Inert atmosphere

5: platinum(IV) oxide; hydrogen / ethyl acetate / 6.25 h / 20 °C

With platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; di-isopropyl azodicarboxylate; hydrogen; triethylamine; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; methanol; hexane; ethyl acetate; toluene;

Reference yield:

: 1222139-48-1
3-[[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethynyl]phenylmethanol

: 1222139-50-5
[3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenyl]methanol

Guidance literature:: With hydrogen; platinum(IV) oxide; In ethyl acetate; at 20 ℃; for 6.25h; under 750.075 Torr;

Reference yield:

: 186593-31-7
(S)-2-(5-bromo-pyridin-3-yloxymethyl)-azetidine-1-carboxylic acid tert-butyl ester

: 1222139-50-5
[3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenyl]methanol

Guidance literature:: Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine / 16 h / Reflux; Inert atmosphere

2: potassium hydroxide / methanol; hexane / 3 h / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / hexane; ethyl acetate / 18.5 h / 20 °C / Inert atmosphere

4: platinum(IV) oxide; hydrogen / ethyl acetate / 6.25 h / 20 °C

With platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; triethylamine; triphenylphosphine; potassium hydroxide; In methanol; hexane; ethyl acetate;