(2R,3S)-N-ethyl 3-(4-methoxyphenyl)glycidamide

Base Information

Chemical Name:(2R,3S)-N-ethyl 3-(4-methoxyphenyl)glycidamide
CAS No.:251090-12-7
Molecular Formula:C₁₂H₁₅NO₃
Molecular Weight:221.256
Hs Code.:

Synonyms:(2R,3S)-N-ethyl 3-(4-methoxyphenyl)glycidamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-N-ethyl 3-(4-methoxyphenyl)glycidamide

Chemical Property:

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Technology Process of (2R,3S)-N-ethyl 3-(4-methoxyphenyl)glycidamide

There total 2 articles about (2R,3S)-N-ethyl 3-(4-methoxyphenyl)glycidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23784-73-8
(E)-4-methoxycinnamic acid ethylamide

: 251090-12-7
(2R,3S)-N-ethyl 3-(4-methoxyphenyl)glycidamide

: (2S,3R)-3-(4-methoxyphenyl)glycidic ethylamide

Guidance literature:: With Oxone; (R)dinaphtho[2,1-g:1,2-i][1,5]dioxacycloundecin-3,6,9-trione; sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; at 10 - 27 ℃; for 26h; Title compound not separated from byproducts;
DOI:10.1021/jo049893u

Reference yield:

: 943-89-5
(E)-3-(4-methoxyphenyl)acrylic acid

: 251090-12-7
(2R,3S)-N-ethyl 3-(4-methoxyphenyl)glycidamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-carbonyldiimidazole / CH₂Cl₂ / 0.5 h / 20 °C

1.2: 67 percent / CH₂Cl₂ / 1 h / 20 °C

2.1: Oxone; NaHCO₃; (R)dinaphtho[2,1-g:1,2-i][1,5]dioxacycloundecin-3,6,9-trione / H₂O; 1,2-dimethoxy-ethane / 26 h / 10 - 27 °C

With Oxone; (R)dinaphtho[2,1-g:1,2-i][1,5]dioxacycloundecin-3,6,9-trione; sodium hydrogencarbonate; 1,1'-carbonyldiimidazole; In 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1021/jo049893u

Reference yield: 61.0%

: 75-03-6
ethyl iodide

: 251090-12-7
(2R,3S)-N-ethyl 3-(4-methoxyphenyl)glycidamide

: (2R,3S)-N,N-diethyl 3-(4-methoxyphenyl)glycidamide

Guidance literature:: (2R,3S)-N-ethyl 3-(4-methoxyphenyl)glycidamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

ethyl iodide; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;
DOI:10.1016/S0957-4166(99)00289-X