Chemical Property of Lapatinib ditosylate
Chemical Property:
- Appearance/Colour:colourless to light-yellow crystal
- Melting Point:237 - 239 °C
- Boiling Point:750.7 °C at 760 mmHg
- Flash Point:407.8 °C
- PSA：249.46000
- Density:1.381 g/cm3
- LogP:12.26450
- Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:15
- Rotatable Bond Count:13
- Exact Mass:924.1735629
- Heavy Atom Count:62
- Complexity:1100
- Purity/Quality:
-
99% *data from raw suppliers
Lapatinib Ditosylate *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi,
N
- Hazard Codes:Xi,N
- MSDS Files:
-
Useful:
- Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
- Recent ClinicalTrials:Paclitaxel and Trastuzumab With or Without Lapatinib in Treating Patients With Stage II or Stage III Breast Cancer That Can Be Removed by Surgery
- Recent EU Clinical Trials:The ROME trial from histology to target: the road to personalize target therapy and immunotherapy
-
Uses
anticancer binds to a(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors atypical antipsychotic agent Lapatinib ditosylate monohydrate is a form of Lapatinib I, an orally active drug for breast cancer as a dual EGFR and erbB-?2 inhibitor.
