O-phenyl [(2R)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-hydroxybutan-2-yl]carbamothioate

Base Information

Chemical Name:O-phenyl [(2R)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-hydroxybutan-2-yl]carbamothioate
CAS No.:1397262-13-3
Molecular Formula:C₂₇H₃₃NO₃SSi
Molecular Weight:479.715
Hs Code.:

Synonyms:O-phenyl [(2R)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-hydroxybutan-2-yl]carbamothioate

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Chemical Property of O-phenyl [(2R)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-hydroxybutan-2-yl]carbamothioate

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Technology Process of O-phenyl [(2R)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-hydroxybutan-2-yl]carbamothioate

There total 4 articles about O-phenyl [(2R)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-hydroxybutan-2-yl]carbamothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3R)-3-amino-4-{[tert-butyl(diphenyl)silyl]oxy}butan-1-ol

: 1005-56-7
phenylcarbonochloridothioate

: 1397262-13-3
O-phenyl [(2R)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-hydroxybutan-2-yl]carbamothioate

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; water; at 0 - 20 ℃; for 0.5h;
DOI:10.1021/jm3008008

Reference yield:

: 1397262-11-1
(3R)-4-{[tert-butyl(diphenyl)silyl]oxy}-3-(dibenzylamino)butan-1-ol

: 1397262-13-3
O-phenyl [(2R)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-hydroxybutan-2-yl]carbamothioate

Guidance literature:: Multi-step reaction with 2 steps

1: 10% Pd/C; ammonium formate / ethanol / 4 h / 20 °C / Reflux

2: sodium hydrogencarbonate / dichloromethane; water / 0.5 h / 0 - 20 °C

With 10% Pd/C; ammonium formate; sodium hydrogencarbonate; In ethanol; dichloromethane; water;
DOI:10.1021/jm3008008

Reference yield:

: 616890-44-9
(2R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(dibenzylamino)butan-1-ol

: 1397262-13-3
O-phenyl [(2R)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-hydroxybutan-2-yl]carbamothioate

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 15 h / 20 °C

2: hydrogenchloride / 1,4-dioxane; water / 1 h / 20 °C

3: 10% Pd/C; ammonium formate / ethanol / 4 h / 20 °C / Reflux

4: sodium hydrogencarbonate / dichloromethane; water / 0.5 h / 0 - 20 °C

With 1H-imidazole; hydrogenchloride; 10% Pd/C; ammonium formate; sodium hydrogencarbonate; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm3008008