(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile

Base Information

Chemical Name:(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile
CAS No.:959691-71-5
Molecular Formula:C₂₀H₁₉N₃O₄
Molecular Weight:365.389
Hs Code.:

Synonyms:(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile

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Chemical Property of (R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile

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Technology Process of (R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile

There total 8 articles about (R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 959694-12-3
(R)-4-[2,5-dioxo-4-(4-methoxyphenyl)-4-methylimidazolidin-1-yl]-2-methoxybenzonitrile

: 74-88-4
methyl iodide

: 959691-71-5
(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl acetamide; mineral oil; at 20 ℃; for 3h;

Reference yield:

: 84954-08-5
4-cyano-3-methoxyphenyl isocyanate

: 959691-71-5
(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

2.1: sodium hydride / N,N-dimethyl acetamide; mineral oil / 0 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl acetamide; mineral oil;
DOI:10.1021/jm300249m

Reference yield:

: 22927-78-2
5-(4-methoxyphenyl)-5-methyl-2,4-imidazolidinedione

: 959691-71-5
(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / 64 h / Inert atmosphere; Reflux

2.1: (R)-1-phenyl-ethyl-amine / ethanol / 20 - 40 °C / Inert atmosphere

2.2: 0.75 h / 20 °C / pH 1 / Inert atmosphere

3.1: hydrogenchloride / 3 h / Inert atmosphere; Reflux

4.1: hydrogenchloride / 0 °C / Inert atmosphere; Reflux

4.2: Inert atmosphere

5.1: triethylamine / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

6.1: sodium hydride / N,N-dimethyl acetamide; mineral oil / 0 °C / Inert atmosphere

6.2: 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; (R)-1-phenyl-ethyl-amine; sodium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide; mineral oil;
DOI:10.1021/jm300249m