(R)-3-(4-cyano-phenyl)-N-(3,5-dichloro-4-fluoro-phenyl)-2-[3-(2,2-dimethoxy-ethyl)-ureido]-2-methyl-propionamide

Base Information

Chemical Name:(R)-3-(4-cyano-phenyl)-N-(3,5-dichloro-4-fluoro-phenyl)-2-[3-(2,2-dimethoxy-ethyl)-ureido]-2-methyl-propionamide
CAS No.:1159735-65-5
Molecular Formula:C₂₂H₂₃Cl₂FN₄O₄
Molecular Weight:497.353
Hs Code.:

Synonyms:(R)-3-(4-cyano-phenyl)-N-(3,5-dichloro-4-fluoro-phenyl)-2-[3-(2,2-dimethoxy-ethyl)-ureido]-2-methyl-propionamide

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Chemical Property of (R)-3-(4-cyano-phenyl)-N-(3,5-dichloro-4-fluoro-phenyl)-2-[3-(2,2-dimethoxy-ethyl)-ureido]-2-methyl-propionamide

Chemical Property:

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Technology Process of (R)-3-(4-cyano-phenyl)-N-(3,5-dichloro-4-fluoro-phenyl)-2-[3-(2,2-dimethoxy-ethyl)-ureido]-2-methyl-propionamide

There total 9 articles about (R)-3-(4-cyano-phenyl)-N-(3,5-dichloro-4-fluoro-phenyl)-2-[3-(2,2-dimethoxy-ethyl)-ureido]-2-methyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 875210-74-5
(2,2-dimethoxy-ethyl)-carbamic acid phenyl ester

: 1159735-63-3
(R)-2-(4-cyano-phenyl)-1-(3,5-dichloro-4-fluoro-phenylcarbamoyl)-1-methyl-ethyl-ammonium toluene-4-sulfonate

: 1159735-65-5
(R)-3-(4-cyano-phenyl)-N-(3,5-dichloro-4-fluoro-phenyl)-2-[3-(2,2-dimethoxy-ethyl)-ureido]-2-methyl-propionamide

Guidance literature:: With 4-methyl-morpholine; sodium phosphate; In dimethyl sulfoxide; at 65 ℃; for 6h;

Reference yield:

: 1159735-51-9
[(R)-1-(3,5-dichloro-4-fluoro-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

: 1159735-65-5
(R)-3-(4-cyano-phenyl)-N-(3,5-dichloro-4-fluoro-phenyl)-2-[3-(2,2-dimethoxy-ethyl)-ureido]-2-methyl-propionamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / methanol; dichloromethane; water / 20 °C

2.1: pivalaldehyde / toluene / 22 h / 50 °C

3.1: triethylamine / 2 h / 0 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / -20 - -5 °C / Inert atmosphere

4.2: -10 - 0 °C

5.1: sodium hydroxide / tetrahydrofuran; water / 6.5 h / 0 °C

5.2: 1.5 h / 50 °C

6.1: acetonitrile / 60 °C

7.1: 4-methyl-morpholine; potassium phosphate / dimethyl sulfoxide / 6 h / 65 °C

With 4-methyl-morpholine; hydrogenchloride; potassium phosphate; pivalaldehyde; triethylamine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile;

Reference yield:

: 1159735-55-3
(2S,5R)-2-tert-butyl-3-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-imidazolidin-4-one

: 1159735-65-5
(R)-3-(4-cyano-phenyl)-N-(3,5-dichloro-4-fluoro-phenyl)-2-[3-(2,2-dimethoxy-ethyl)-ureido]-2-methyl-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / 2 h / 0 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -20 - -5 °C / Inert atmosphere

2.2: -10 - 0 °C

3.1: sodium hydroxide / tetrahydrofuran; water / 6.5 h / 0 °C

3.2: 1.5 h / 50 °C

4.1: acetonitrile / 60 °C

5.1: 4-methyl-morpholine; potassium phosphate / dimethyl sulfoxide / 6 h / 65 °C

With 4-methyl-morpholine; potassium phosphate; triethylamine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; water; dimethyl sulfoxide; acetonitrile;