Technology Process of 1-(2-Bromo-3-ethoxy phenyl)ethanone
There total 4 articles about 1-(2-Bromo-3-ethoxy phenyl)ethanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(2-bromo-3-hydroxy phenyl)ethanone;
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
ethyl iodide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 21h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / acetonitrile / 17 h / 20 °C
2.1: tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere
3.1: phosphorus tribromide / dichloromethane / 22 h / -80 - -40 °C / Inert atmosphere
3.2: 3 h / -80 - -40 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere
4.2: 21 h / 20 °C
With
4-methyl-morpholine; phosphorus tribromide; potassium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere
2.1: phosphorus tribromide / dichloromethane / 22 h / -80 - -40 °C / Inert atmosphere
2.2: 3 h / -80 - -40 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere
3.2: 21 h / 20 °C
With
phosphorus tribromide; potassium carbonate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
