2-methyl 1-(phenylmethyl) (+/-)-4-<3-(diethoxyphosphinyl)propyl>-1,2-piperazinedicarboxylate

Base Information

• Chemical Name: 2-methyl 1-(phenylmethyl) (+/-)-4-<3-(diethoxyphosphinyl)propyl>-1,2-piperazinedicarboxylate
• CAS No.: 126937-45-9
• Molecular Formula: C₂₁H₃₃N₂O₇P
• Molecular Weight: 456.476
• Mol file: 126937-45-9.mol

Synonyms:2-methyl 1-(phenylmethyl) (+/-)-4-<3-(diethoxyphosphinyl)propyl>-1,2-piperazinedicarboxylate

Chemical Property of 2-methyl 1-(phenylmethyl) (+/-)-4-<3-(diethoxyphosphinyl)propyl>-1,2-piperazinedicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl 1-(phenylmethyl) (+/-)-4-<3-(diethoxyphosphinyl)propyl>-1,2-piperazinedicarboxylate

There total 6 articles about 2-methyl 1-(phenylmethyl) (+/-)-4-<3-(diethoxyphosphinyl)propyl>-1,2-piperazinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-pyrazylcarboxylic acid (98-97-5) → 2-methyl 1-(phenylmethyl) (+/-)-4-<3-(diethoxyphosphinyl)propyl>-1,2-piperazinedicarboxylate (126937-45-9)

Guidance literature:

Multi-step reaction with 6 steps

1: NaOH, H₂ / 20percent Pd/C / H₂O / 2585.7 Torr

2: 50percent aq. NaOH / H₂O; dioxane / 3 h

3: 50percent aq. NaOH / 24 h / Ambient temperature

4: tetrahydrofuran

5: CF₃COOH / CH₂Cl₂

6: Na₂CO₃ / ethanol / 12 h / Heating

With sodium hydroxide; hydrogen; sodium carbonate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

DOI:10.1016/S0040-4039(01)93739-6

Reference yield:

4-(2-tert-Butoxy-acetyl)-piperazine-2-carboxylic acid → 2-methyl 1-(phenylmethyl) (+/-)-4-<3-(diethoxyphosphinyl)propyl>-1,2-piperazinedicarboxylate (126937-45-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 50percent aq. NaOH / 24 h / Ambient temperature

2: tetrahydrofuran

3: CF₃COOH / CH₂Cl₂

4: Na₂CO₃ / ethanol / 12 h / Heating

With sodium hydroxide; sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/S0040-4039(01)93739-6

Reference yield:

1,2,4-piperazinetricarboxylic acid,4-(1,1-dimethylethyl) 1-(phenylmethyl) ester → 2-methyl 1-(phenylmethyl) (+/-)-4-<3-(diethoxyphosphinyl)propyl>-1,2-piperazinedicarboxylate (126937-45-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran

2: CF₃COOH / CH₂Cl₂

3: Na₂CO₃ / ethanol / 12 h / Heating

With sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/S0040-4039(01)93739-6

upstream raw materials:

diethyl 3-(bromopropyl)phosphonic acid

2-methyl 1-phenylmethyl 1,2-piperazinedicarboxilate, trifluoroacetate

2-pyrazylcarboxylic acid

piperazine-2-carboxylic acid

Downstream raw materials:

(+/-)-1-(3,3-diphenylpropyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid

(+/-)-1-(4,4-diphenyl-3-butenyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid

(+/-)-1-(4-phenylbutyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid