2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanone

Base Information

Chemical Name:2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanone
CAS No.:1374004-95-1
Molecular Formula:C₃₈H₃₃NO₆S
Molecular Weight:631.749
Hs Code.:

Synonyms:2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanone

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Chemical Property of 2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanone

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Technology Process of 2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanone

There total 4 articles about 2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1374004-91-7
2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanol

: 1374004-95-1
2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanone

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 20 ℃; for 2h;
DOI:10.1016/j.tet.2012.03.026

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 1374004-95-1
2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / tetrahydrofuran; water / 1 h / Reflux

3.1: propionic acid; phenylboronic acid / toluene / 20 h / Reflux

3.2: 0.5 h / 0 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2 h / 20 °C

With hydrogenchloride; potassium tert-butylate; potassium carbonate; propionic acid; phenylboronic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2012.03.026

Reference yield:

: 16209-52-2
<4-(benzyloxy)-3-methoxyphenyl>acetaldehyde

: 1374004-95-1
2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: propionic acid; phenylboronic acid / toluene / 20 h / Reflux

1.2: 0.5 h / 0 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2 h / 20 °C

With potassium carbonate; propionic acid; phenylboronic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2012.03.026