C₂₂H₂₂FN₃O₂

Base Information

Chemical Name:C₂₂H₂₂FN₃O₂
CAS No.:1383735-27-0
Molecular Formula:C₂₂H₂₂FN₃O₂
Molecular Weight:379.434
Hs Code.:

C<sub>22</sub>H<sub>22</sub>FN<sub>3</sub>O<sub>2</sub>

Synonyms:C₂₂H₂₂FN₃O₂

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Chemical Property of C₂₂H₂₂FN₃O₂

Chemical Property:

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Technology Process of C₂₂H₂₂FN₃O₂

There total 9 articles about C₂₂H₂₂FN₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 405174-97-2
3-bromopicolinaldehyde

: 1383735-27-0
C₂₂H₂₂FN₃O₂

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium acetate / ethanol; water / 18 h / 50 °C

2.1: potassium carbonate / cis-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide / 1-methyl-pyrrolidin-2-one / 18 h / 120 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 61 h

4.1: acetic anhydride / 28 h / 140 °C / sealed tube

4.2: 6 h / 90 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; water; methanol

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 5 °C

6.2: 16 h / 20 °C

7.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 0.5 h / -78 °C

7.2: 2 h

8.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

8.2: 2 h

With hydrogen; sodium acetate; acetic anhydride; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; copper(l) iodide; palladium 10% on activated carbon; cis-N,N'-dimethyl-1,2-diaminocyclohexane; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1383735-26-9
C₂₁H₂₀FN₃O₂

: 74-88-4
methyl iodide

: 1383735-27-0
C₂₂H₂₂FN₃O₂

Guidance literature:: C₂₁H₂₀FN₃O₂; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; for 2h;

Reference yield:

: (4-fluoro-phenyl)-hydrazine hydrochloride

: 1383735-27-0
C₂₂H₂₂FN₃O₂

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium acetate / ethanol; water / 18 h / 50 °C

2.1: potassium carbonate / cis-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide / 1-methyl-pyrrolidin-2-one / 18 h / 120 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 61 h

4.1: acetic anhydride / 28 h / 140 °C / sealed tube

4.2: 6 h / 90 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; water; methanol

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 5 °C

6.2: 16 h / 20 °C

7.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 0.5 h / -78 °C

7.2: 2 h

8.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

8.2: 2 h

With hydrogen; sodium acetate; acetic anhydride; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; copper(l) iodide; palladium 10% on activated carbon; cis-N,N'-dimethyl-1,2-diaminocyclohexane; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;