(E)-N-[6-(2-hydroxybutoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethenesulfonamide

Base Information

Chemical Name:(E)-N-[6-(2-hydroxybutoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethenesulfonamide
CAS No.:351019-95-9
Molecular Formula:C₂₇H₂₇N₅O₆S
Molecular Weight:549.607
Hs Code.:

Synonyms:(E)-N-[6-(2-hydroxybutoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethenesulfonamide

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Chemical Property of (E)-N-[6-(2-hydroxybutoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethenesulfonamide

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Technology Process of (E)-N-[6-(2-hydroxybutoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethenesulfonamide

There total 3 articles about (E)-N-[6-(2-hydroxybutoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64984-09-4
(E)-(2-phenylethenyl)sulfonamide

: 351019-95-9
(E)-N-[6-(2-hydroxybutoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 93 percent / dimethylformamide / 2 h / 20 °C

2.1: Na / 60 °C

2.2: 3 h / 80 °C

With sodium; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.49.606

Reference yield:

: 150728-13-5
4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

: 351019-95-9
(E)-N-[6-(2-hydroxybutoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 93 percent / dimethylformamide / 2 h / 20 °C

2.1: Na / 60 °C

2.2: 3 h / 80 °C

With sodium; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.49.606

Reference yield:

: 110-63-4
Butane-1,4-diol

: 351019-39-1
N-[6-Chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamide

: 351019-95-9
(E)-N-[6-(2-hydroxybutoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethenesulfonamide

Guidance literature:: Butane-1,4-diol; With sodium; at 60 ℃;

N-[6-Chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamide; at 80 ℃; for 3h;
DOI:10.1248/cpb.49.606