64984-09-4

Upstream product

• 52147-97-4 trans 2-phenylethenesulfonyl chloride 
• 108-86-1 bromobenzene 
• 2386-58-5 vinyl sulfonamide 
• 591-50-4 iodobenzene 
• 208395-41-9 2-Cyclohexyl-3-phenyl-4,4-bis-trimethylsilanyl-[1,2]thiazetidine 1,1-dioxide 
• 10026-13-8 phosphorus pentachloride 
• 18585-53-0 1-phenyl-ethane-1,2-disulfonic acid 
• 98-85-1 1-Phenylethanol 
• 100-42-5 styrene 
• 97273-03-5 2-Cyclohexyl-3-phenyl-1,2-thiazetidin-1,1-dioxid 
• 2211-66-7 N-phenyl(methylidene)cyclohexanamine 
• 1028072-66-3 tert-butyl N-(E)-styrylsulfonylcarbamate 

Downstream Products

• 57185-65-6 2c-phenyl-ethenesulfonic acid amide 
• 134641-05-7 (E)-2-Phenyl-ethenesulfonic acid benzoylamide 
• 351019-39-1 N-[6-Chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamide 
• 64984-23-2 (E)-β-bromo-styrene-β-sulfonic acid amide 
• 64984-22-1 (Z)-1-bromo-2-phenyl-ethenesulfonic acid amide 
• 56753-55-0 N-(4-[3-phenylpropyl]piperidinocarbonyl)-2-phenylethenesulfonamide 

Relevant academic research and scientific papers

Highly efficient azido-Ugi multicomponent reactions for the synthesis of bioactive tetrazoles bearing sulfonamide scaffolds

Recent studies revealed that the contribution of the different bioactive scaffolds in one structure creates modern drugs/compounds with unique synergistic biological properties. In this regard, thanks to the interesting biological and medicinal properties

NOVEL SUBSTITUTED SULFONYLUREA DERIVATIVES

The present invention relates to novel heterocyclic compounds of the general formula (I) their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers and polymorphs. The invention also relates to processes for

Green approach for the synthesis of thiophenyl pyrazoles and isoxazoles by adopting 1,3-dipolar cycloaddition methodology and their antimicrobial activity

A variety of N-((1,3-diphenyl-5-aryl-1H-pyrazol-4-yl)sulfonyl)thiophene-2-carboxamides (7) and N-((5-aryl-3-phenylisoxazol-4-yl)sulfonyl)thiophene-2-carboxamides (8) were prepared from (E)-N-(arylethenesulfonyl)thiophene-2-carboxamides (4) adopting 1,3-di

SYNTHESIS OF SUBSTITUTED PYRAZOLINE CARBOXAMIDINE DERIVATIVES

This invention relates to organic chemistry, in particular to processes for the preparation of pyrazoline carboxamidine derivatives of formula (I), known as potent 5-HT6 antagonists. The invention also relates to novel intermediates of these compounds. wh

NOVEL DIHYDROXYPYRROLIDINE DERIVATIVES AS ANTI-CANCER AGENTS

The present invention provides new dihydroxypyrrolidine derivatives for use as medicaments. The compounds are useful in the treatment in cancer, in particular non-solid neoplasms.

Synthesis of E-aryl ethenesulfonamides: A simple one-pot, two-step procedure from 1-hydroxy-1-arylalkanes

The unusual reactivity of 1-phenyl-1-ethane-sulfonic acid in thionyl chloride was investigated. Mechanistic considerations led us to set up a new and efficient synthesis of E-arylethenesulfonamides starting from 1-hydroxy-1-arylalkanes. The easy availability of the starting materials and the straightforward, one-pot procedure make this process an attractive method for the preparation of these compounds currently largely employed in chemical and pharmaceutical fields.

Synthesis of Vinyl Sulfonamides Using the Horner Reaction

A series of vinyl sulfonamides was synthesized using the Horner reaction of aldehydes and diphenylphosphorylmethane-sulfonamide. The sulfonamide reagent was easily prepared and can be stored indefinitely. The trans orientation about the double bond of the vinyl sulfonamides was the only isomer observed.

Stereospecific C-N bond cleavage of 4-silylated 1,2-thiazetidine 1,1- dioxides with EtAlCl2 or AlCl3: Formation of (E)-vinylsulfonamides

Monosilylation of 1,2-thiazetidine 1,1-dioxides (β-sultams) 3 gave (3R*, 4S*)-4-monosilyl-β-sultams 4 stereoselectively. Disilylated β- sultams 5 were obtained by the use of trimethylsilyl chloride. Treatment of 4-monosilyl-β-sultams 4 with EtAlCl2 caused stereospecific C-N bond cleavage owing to β-cation stabilization of the silicon group to provide (E)-vinylsulfonamides (E)-7. (E)-α-Silylstyrylsulfonamides (E)-7j - l were generated in the reaction of 4,4-disilyl-β-sultams 5 with EtAlCl2. Reaction of 4-silyl-β-sultams with AlCl3 afforded N-dealkylated (E)- vinylsulfonamides in good yields. Reaction of (E)-α-silylstyrylsulfonamide (E)-10 with benzaldehyde in the presence of tetrabutylammonium fluoride and BF3·Et2O provided the allylic alcohol (E)-12.

Palladium-Catalyzed Synthesis of N-Benzoyl-2-arylethenesulfonamides from (2-(Benzoylsulfamoyl)ethyl)pyridinium Chloride and Aryl Halides

A new, general synthesis of N-benzoyl-2-arylethenesulfonamides by the reaction of aryl halides including heteroaryl halides with (2-(benzoylsulfamoyl)ethyl)pyridinium chloride in the presence of palladium acetate is described.