N-[6-Chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamide

Base Information

• Chemical Name: N-[6-Chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamide
• CAS No.: 351019-39-1
• Molecular Formula: C₂₃H₁₈ClN₅O₄S
• Molecular Weight: 495.946
• Mol file: 351019-39-1.mol

Synonyms:N-[6-Chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamide

Chemical Property of N-[6-Chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[6-Chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamide

There total 1 articles about N-[6-Chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(E)-(2-phenylethenyl)sulfonamide (64984-09-4) + 4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine (150728-13-5) → N-[6-Chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamide (351019-39-1)

Guidance literature:

(E)-(2-phenylethenyl)sulfonamide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1248/cpb.49.606

Reference yield: 96.0%

ethylene glycol (107-21-1) + N-[6-Chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamide (351019-39-1) → N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamide

Guidance literature:

ethylene glycol; With sodium; at 60 ℃;

N-[6-Chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamide; at 80 ℃; for 3h;

DOI:10.1248/cpb.49.606

Reference yield: 88.0%

N-[6-Chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamide (351019-39-1) + trimethyleneglycol (504-63-2) → N-[6-(3-hydroxypropyloxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamide

Guidance literature:

trimethyleneglycol; With sodium; at 60 ℃;

N-[6-Chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamide; at 80 ℃; for 3h;

DOI:10.1248/cpb.49.606

upstream raw materials:

(E)-(2-phenylethenyl)sulfonamide

4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

Downstream raw materials:

(E)-N-[6-(2-hydroxybutoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethenesulfonamide

[5-(2-Methoxy-phenoxy)-6-((E)-2-phenyl-ethenesulfonylamino)-[2,2']bipyrimidinyl-4-yloxy]-acetic acid ethyl ester

(E)-2-Phenyl-ethenesulfonic acid [6-(2-amino-ethoxy)-5-(2-methoxy-phenoxy)-[2,2']bipyrimidinyl-4-yl]-amide