piperidine-4-carboxylic acid cyclohexylamide hydrochloride

Base Information

• Chemical Name: piperidine-4-carboxylic acid cyclohexylamide hydrochloride
• CAS No.: 1019851-98-9
• Molecular Formula: C₁₂H₂₂N₂O*ClH
• Molecular Weight: 246.78
• Mol file: 1019851-98-9.mol

Synonyms:piperidine-4-carboxylic acid cyclohexylamide hydrochloride

Chemical Property of piperidine-4-carboxylic acid cyclohexylamide hydrochloride

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of piperidine-4-carboxylic acid cyclohexylamide hydrochloride

There total 5 articles about piperidine-4-carboxylic acid cyclohexylamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ piperidine-4-carboxylic acid cyclohexylamide hydrochloride (1019851-98-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 2h;

Reference yield: 97.0%

N-cyclohexylisonicotinamide (10354-59-3) → piperidine-4-carboxylic acid cyclohexylamide hydrochloride (1019851-98-9)

Guidance literature:

With 1,1,2-trichloroethane; palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 9h; under 760.051 Torr;

DOI:10.1016/j.tet.2009.08.011

Reference yield:

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → piperidine-4-carboxylic acid cyclohexylamide hydrochloride (1019851-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide

2: hydrogenchloride / methanol; water / 18 h

With hydrogenchloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.10.040

upstream raw materials:

N-cyclohexylisonicotinamide

tert-butyl 4-(cyclohexylcarbamoyl)piperidine-1-carboxylate

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

cyclohexylamine

Downstream raw materials:

C₁₉H₂₄ClN₃O₂