N-methyl-4-(4-(4-(4-hydroxyphenyl)thiazol-2-ylamino)phenoxy)picolinamide

Base Information

Chemical Name:N-methyl-4-(4-(4-(4-hydroxyphenyl)thiazol-2-ylamino)phenoxy)picolinamide
CAS No.:1310739-79-7
Molecular Formula:C₂₂H₁₈N₄O₃S
Molecular Weight:418.476
Hs Code.:

Synonyms:N-methyl-4-(4-(4-(4-hydroxyphenyl)thiazol-2-ylamino)phenoxy)picolinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-methyl-4-(4-(4-(4-hydroxyphenyl)thiazol-2-ylamino)phenoxy)picolinamide

Chemical Property:

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Technology Process of N-methyl-4-(4-(4-(4-hydroxyphenyl)thiazol-2-ylamino)phenoxy)picolinamide

There total 6 articles about N-methyl-4-(4-(4-(4-hydroxyphenyl)thiazol-2-ylamino)phenoxy)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 2491-38-5
2-bromo-1-(4'-hydroxyphenyl)-1-ethanone

: 1310739-63-9
N-methyl-4-(4-thioureidophenoxy)picolinamide

: 1310739-79-7
N-methyl-4-(4-(4-(4-hydroxyphenyl)thiazol-2-ylamino)phenoxy)picolinamide

Guidance literature:: In ethanol; at 60 ℃; for 1h;
DOI:10.3390/molecules16065130

Reference yield:

: 98-98-6
2-Picolinic acid

: 1310739-79-7
N-methyl-4-(4-(4-(4-hydroxyphenyl)thiazol-2-ylamino)phenoxy)picolinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 17.5 h / 50 °C / Inert atmosphere; Reflux

2.1: tetrahydrofuran; methanol / 0 - 20 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 6 h / 80 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / dichloromethane / 0.33 h / 0 °C

4.2: 5 h / 20 °C

5.1: ammonium hydroxide / 1,4-dioxane / 1 h / 0 °C

6.1: ethanol / 1 h / 60 °C

With ammonium hydroxide; thionyl chloride; potassium tert-butylate; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3390/molecules16065130

Reference yield:

: 284462-37-9
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

: 1310739-79-7
N-methyl-4-(4-(4-(4-hydroxyphenyl)thiazol-2-ylamino)phenoxy)picolinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / dichloromethane / 0.33 h / 0 °C

1.2: 5 h / 20 °C

2.1: ammonium hydroxide / 1,4-dioxane / 1 h / 0 °C

3.1: ethanol / 1 h / 60 °C

With ammonium hydroxide; sodium hydrogencarbonate; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.3390/molecules16065130