N₁-(4-methoxyphenyl)-N₁-(2-oxo-2-phenylethyl)-2-phenylacetamide

Base Information

• Chemical Name: N₁-(4-methoxyphenyl)-N₁-(2-oxo-2-phenylethyl)-2-phenylacetamide
• CAS No.: 705972-14-1
• Molecular Formula: C₂₃H₂₁NO₃
• Molecular Weight: 359.425
• Mol file: 705972-14-1.mol

Synonyms:N₁-(4-methoxyphenyl)-N₁-(2-oxo-2-phenylethyl)-2-phenylacetamide

Chemical Property of N₁-(4-methoxyphenyl)-N₁-(2-oxo-2-phenylethyl)-2-phenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-(4-methoxyphenyl)-N₁-(2-oxo-2-phenylethyl)-2-phenylacetamide

There total 3 articles about N₁-(4-methoxyphenyl)-N₁-(2-oxo-2-phenylethyl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

2-((4-methoxyphenyl)amino)-1-phenylethanone (5883-82-9) + phenylacetyl chloride (103-80-0) → N1-(4-methoxyphenyl)-N1-(2-oxo-2-phenylethyl)-2-phenylacetamide (705972-14-1)

Guidance literature:

In tetrahydrofuran; at 25 ℃; for 2h;

DOI:10.1016/j.tet.2004.03.036

Reference yield:

4-methoxy-aniline (104-94-9) → N1-(4-methoxyphenyl)-N1-(2-oxo-2-phenylethyl)-2-phenylacetamide (705972-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / NaHCO₃ / ethanol / 6 h / 25 °C

2: 31 percent / tetrahydrofuran / 2 h / 25 °C

With sodium hydrogencarbonate; In tetrahydrofuran; ethanol;

DOI:10.1016/j.tet.2004.03.036

Reference yield:

α-bromoacetophenone (70-11-1) → N1-(4-methoxyphenyl)-N1-(2-oxo-2-phenylethyl)-2-phenylacetamide (705972-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / NaHCO₃ / ethanol / 6 h / 25 °C

2: 31 percent / tetrahydrofuran / 2 h / 25 °C

With sodium hydrogencarbonate; In tetrahydrofuran; ethanol;

DOI:10.1016/j.tet.2004.03.036

upstream raw materials:

2-((4-methoxyphenyl)amino)-1-phenylethanone

phenylacetyl chloride

4-methoxy-aniline

α-bromoacetophenone

Downstream raw materials:

1-(4-methoxyphenyl)-3,4-diphenyl-2,5-dihydro-1H-2,5-azoledione